Document Detail

Successful pregnancy and delivery after delaying the initiation of progesterone supplementation in a postmenopausal donor oocyte recipient.
MedLine Citation:
PMID:  15670404     Owner:  NLM     Status:  MEDLINE    
Progesterone luteal support has become a standard procedure during IVF cycles. Donor egg cycle women without inherent ovarian function require complete hormone replacement, in contrast with women undergoing IVF in which luteal support is used to supplement endogenous progesterone production. Progesterone support is clearly beneficial, although the timing of its initiation can affect overall outcomes. This paper describes a case in which a postmenopausal woman attending for oocyte donation did not receive her first progesterone injection at the correct time. Treatment with progesterone began when she arrived for the transfer of the donor embryos. The two embryos were maintained in culture and one was transferred on day 6 when the delayed progesterone administration had induced a secretory transformation in her endometrium. A single gestation sac was recorded 8 weeks later, and a healthy baby was subsequently born. On the morning of day 6, delayed progesterone supplementation had induced the secretory endometrial transformation typical of the second phase of the menstrual cycle.
Alvaro Alosilla Fonttis; Roxana Napolitano; Carlos Borda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  9     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-26     Completed Date:  2005-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  611-3     Citation Subset:  IM    
Centro de Reproducción, 41 No. 485, La Plata (1900), Buenos Aires, Argentina.
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MeSH Terms
Administration, Intravaginal
Delivery, Obstetric*
Drug Administration Schedule
Embryo Culture Techniques
Embryo Transfer
Endometrium / drug effects
Oocyte Donation*
Progesterone / administration & dosage*,  therapeutic use
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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