Document Detail

Successful pregnancy after treatment of a cervical gestational trophoblastic neoplasia: a case report.
MedLine Citation:
PMID:  22324277     Owner:  NLM     Status:  In-Process    
BACKGROUND: Primary gestational trophoblastic neoplasia of the uterine cervix is exceptionally rare, with fewer than 100 cases reported worldwide.
CASE: A 33-year-old, gravida 1, para 1, Filipino woman was admitted due to vaginal bleeding nearly 7 months after delivery of a full-term, stillborn infant. Transvaginal ultrasound revealed a heterogeneous, predominantly solid, vascular mass at the upper half of the cervix measuring 3.05 x 3.75 x 3.6 cm. Serum beta human chorionic gonadotropin (beta-hCG) on admission was 101,922.5 mIU/mL. She was initially treated with single-agent chemotherapy in the form of methotrexate. Rising levels of serum beta-hCG after the third cycle necessitated a shift to multiagent chemotherapy in the form of etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. The patient achieved remission after 6 cycles and eventually achieved a successful pregnancy.
CONCLUSION: Primary gestational trophoblastic neoplasia of the cervix can be treated successfully using chemotherapy.
Angelica A Chua; Agnes L Soriano-Estrella
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  57     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-02-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Philippine General Hospital, University of the Philippines, Manila.
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