| Successful pregnancy after high-dose cyclophosphamide, carboplatinum, and taxol with peripheral blood stem cell transplant in a young woman with ovarian carcinoma. | |
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MedLine Citation:
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PMID: 11606107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Both ovarian carcinoma and high-dose chemotherapy tend to preclude future pregnancies. CASE: We report a case of a young woman with borderline ovarian carcinoma and invasive tumor implants who underwent surgical debulking with preservation of future fertility followed by carboplatinum, paclitaxel (Taxol), and subsequent high-dose chemotherapy with subsequent peripheral blood stem cell rescue as part of a phase I clinical trial. After a brief period of amenorrhea, the patient had a successful pregnancy that was complicated by a spontaneous abortion in the first trimester. Several months later she conceived and delivered a healthy baby at term. CONCLUSIONS: To our knowledge this is the first reported case of pregnancy after high-dose chemotherapy with stem cell transplant in a woman with ovarian carcinoma. |
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Authors:
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M V Seiden; T R Spitzer; S McAfee; A F Fuller |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Gynecologic oncology Volume: 83 ISSN: 0090-8258 ISO Abbreviation: Gynecol. Oncol. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-18 Completed Date: 2001-12-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 412-4 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Academic Press. |
Affiliation:
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Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. mseiden@partners.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Carboplatin / administration & dosage Clinical Trials, Phase I as Topic Combined Modality Therapy Cyclophosphamide / administration & dosage Female Hematopoietic Stem Cell Transplantation* Humans Ovarian Neoplasms / drug therapy, surgery, therapy* Paclitaxel / administration & dosage Pregnancy Pregnancy Complications, Neoplastic* |
| Chemical | |
Reg. No./Substance:
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33069-62-4/Paclitaxel; 41575-94-4/Carboplatin; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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