Document Detail


Successful pregnancy after cyclophosphamide therapy for lupus nephritis.
MedLine Citation:
PMID:  21331538     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Systemic lupus erythematosus (SLE) often requires administration of cyclophosphamide (CYC), especially for severe glomerulonephritis. As this disease usually affects young women in reproductive age, pregnancy, though not recommended may occur. The teratogenic effects of this drug make pregnancy prognosis and fetal survival indeterminate. METHODS: We reviewed retrospectively the medical records of five patients with SLE who received inadvertently CYC during pregnancy and analyzed fetal outcome. RESULTS: All patients were exposed at the first trimester. Two patients suffered miscarriages, two went to full term and one presented premature labor. CONCLUSION: In spite of potential successful pregnancies after CYC exposure, this drug has teratogenic effects and prescription must be avoided during the pregnancy period. At the same time, the occurrence of these reported unplanned pregnancies strengthen the need of improving patients' education on pregnancy risks during immunosuppressive treatment.
Authors:
Gabriela Lannes; Fernanda R Elias; Bernardo Cunha; Nilson Jesus; Evandro M Klumb; Elisa M N Albuquerque; Francinne M Ribeiro
Related Documents :
15731298 - Mechanisms underlying "functional" progesterone withdrawal at parturition.
20021978 - Effect of progesterone and pregnancy on the development of varicose veins.
2199478 - The 24-hour pattern of the levels of serum progesterone and immunoreactive human chorio...
21264878 - Hematological effects of zidovudine prophylaxis in newborn infants with and without pre...
11120518 - Delayed-interval delivery: extended series from a single maternal-fetal medicine practice.
9637638 - Intravenous remifentanil: placental transfer, maternal and neonatal effects.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-18
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  -     ISSN:  1432-0711     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, Rio de Janeiro, RJ, 22220-040, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Recent advances in magnetic resonance imaging in posterior circulation stroke: implications for diag...
Next Document:  Tubal anastomosis after tubal sterilization: a review.