| Successful pregnancy after cyclophosphamide therapy for lupus nephritis. | |
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MedLine Citation:
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PMID: 21331538 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Systemic lupus erythematosus (SLE) often requires administration of cyclophosphamide (CYC), especially for severe glomerulonephritis. As this disease usually affects young women in reproductive age, pregnancy, though not recommended may occur. The teratogenic effects of this drug make pregnancy prognosis and fetal survival indeterminate. METHODS: We reviewed retrospectively the medical records of five patients with SLE who received inadvertently CYC during pregnancy and analyzed fetal outcome. RESULTS: All patients were exposed at the first trimester. Two patients suffered miscarriages, two went to full term and one presented premature labor. CONCLUSION: In spite of potential successful pregnancies after CYC exposure, this drug has teratogenic effects and prescription must be avoided during the pregnancy period. At the same time, the occurrence of these reported unplanned pregnancies strengthen the need of improving patients' education on pregnancy risks during immunosuppressive treatment. |
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Authors:
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Gabriela Lannes; Fernanda R Elias; Bernardo Cunha; Nilson Jesus; Evandro M Klumb; Elisa M N Albuquerque; Francinne M Ribeiro |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-18 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: - ISSN: 1432-0711 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Rheumatology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rua Dois de Dezembro, 131/702 Flamengo, Rio de Janeiro, RJ, 22220-040, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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