Document Detail

Successful pregnancies after oocyte cryopreservation with slow-freezing method: a report of 3 cases.
MedLine Citation:
PMID:  19004412     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The technology for successful oocyte cryopreservation has evolved only over the past decade. Fewer than 300 pregnancies achieved with cryopreserved oocytes were reported as of the end of 2006. Two cryopreservation techniques are currently available: the slow-cooling method and vitrification. This article reviews the world literature on pregnancies conceived from cryopreserved oocytes and reports 3 such pregnancies conceived with a slow-cooling method in our facility. CASES: Three patients who underwent in vitro fertilization/embryo transfer cycles had the supranumerary oocytes cryopreserved using a slow-cooling method. After a period of 2-7 months, the oocytes were thawed, fertilized and the resulting embryos were transferred. All 3 patients conceived and 2 delivered-1 singleton and 1 a set of twins. The third patient conceived twins and was in the third trimester of her pregnancy at this writing. Literature review indicates that the majority of pregnancies to date have been achieved with a slow-cooling protocol. However, recent advances in the vitrification technology have improved its effectiveness and because of its simplicity made it the method of choice in oocyte cryopreservation. CONCLUSION: Both slow-freezing and vitrification methods for oocyte cryopreservation can be used effectively to achieve pregnancies. Vitrification is technically simpler and may be more effective than slow freezing.
Jianchi Ding; Nasir Rana; W Paul Dmowski
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  53     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-13     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  813-20     Citation Subset:  IM    
Oak Brook Fertility Center, Oak Brook, IL 60523, USA.
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MeSH Terms
Cryopreservation / methods*
Embryo Transfer / methods
Fertilization in Vitro / methods*
Oocytes / physiology*
Pregnancy Outcome*
Pregnancy Rate*
Sperm Injections, Intracytoplasmic / methods
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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