Document Detail


Successful parenteral desensitization to paclitaxel.
MedLine Citation:
PMID:  8568136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Paclitaxel, a member of a new class of antineoplastic agents called the taxanes, has been associated with anaphylactoid reactions. OBJECTIVE: We report a case of successful parental desensitization to paclitaxel. METHODS: Desensitization was performed with serial 10-fold dilutions (up to 1:100,000) of paclitaxel in sufficient volume to administer successive doses of 1, 2, 4, and 8 ml. Basophil histamine release tests were performed with paclitaxel alone, vehicle alone, and paclitaxel and vehicle combined to determine which agent was responsible for the anaphylactoid reactions. RESULTS: After parental desensitization was performed, the patient was able to tolerate infusion of paclitaxel without complications or need for antihistamines or steroids. Basophil histamine release occurred only with paclitaxel and not with the vehicle. CONCLUSIONS: Successful parenteral desensitization to paclitaxel can be achieved; it is paclitaxel, and not its vehicle, that is most likely responsible for anaphylactoid reactions in patients undergoing treatment.
Authors:
D M Essayan; A Kagey-Sobotka; P J Colarusso; L M Lichtenstein; R F Ozols; E D King
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  97     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-03-06     Completed Date:  1996-03-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  42-6     Citation Subset:  AIM; IM    
Affiliation:
Division of Clinical Immunology, Johns Hopkins Asthma & Allergy Center, Baltimore, MD 21224, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Agents, Phytogenic / adverse effects*
Cystadenocarcinoma / drug therapy*
Desensitization, Immunologic*
Drug Hypersensitivity / prevention & control*
Female
Humans
Infusions, Parenteral
Ovarian Neoplasms / drug therapy*
Paclitaxel / adverse effects*
Grant Support
ID/Acronym/Agency:
AI 07290/AI/NIAID NIH HHS; AI 08270/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 33069-62-4/Paclitaxel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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