| Successful palliation with octreotide of a neuroendocrine syndrome from malignant melanoma. | |
| | |
MedLine Citation:
|
PMID: 16877188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We present a unique case of a neuroendocrine syndrome in a patient with Stage IV vaginal melanoma metastatic to the liver that was successfully palliated with octreotide. Similar to the carcinoid syndrome, the patient exhibited chronic diaphoresis, intermittent low-grade fevers, dizziness, nausea with vomiting, and hot flashes. The symptoms on admission of acute hypotension, acute exacerbation of abdominal pains, and intractable nausea with vomiting suggested a neuroendocrine crisis secondary to massive degranulation and hormone release. Consistent with our hypothesis, her plasma chromogranin A was found to be elevated. Octreotide was used successfully to palliate her symptoms. When the octreotide was stopped, all her symptoms returned. As the use of octreotide is gaining application in palliative care, this case highlights the effectiveness of its use in a select group of patients whose symptoms would be otherwise difficult to manage. |
| | |
Authors:
|
Alexander W Jahng; Solomon S Liao |
Related Documents
:
|
7823078 - Somatosensory evoked blink response: findings in patients with miller fisher syndrome a... 11246028 - Hantavirus. 20981768 - Advances in understanding behavioral phenotypes in neurogenetic syndromes. 8780958 - To be or not to be at home? a neuropsychological approach to delusion for place. 17242878 - Acute tumor lysis syndrome caused by transcatheter oily chemoembolization in a patient ... 16024358 - First identifiable mesozoic harvestman (opiliones: dyspnoi) from cretaceous burmese amber. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of pain and symptom management Volume: 32 ISSN: 0885-3924 ISO Abbreviation: J Pain Symptom Manage Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-07-31 Completed Date: 2006-09-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8605836 Medline TA: J Pain Symptom Manage Country: United States |
Other Details:
|
Languages: eng Pagination: 191-5 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of California at Irvine Medical Center, Orange, California 92868, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abdominal Pain
/
prevention & control* Chest Pain / prevention & control* Female Gastrointestinal Agents / therapeutic use Humans Liver Neoplasms / drug therapy, secondary* Melanoma / drug therapy, secondary* Middle Aged Neuroendocrine Tumors / drug therapy, secondary Octreotide / therapeutic use* Palliative Care / methods* Syndrome Treatment Outcome Vaginal Neoplasms / drug therapy |
| Chemical | |
Reg. No./Substance:
|
0/Gastrointestinal Agents; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Symptomatic management of calciphylaxis: a case series and review of the literature.
Next Document: Nurses' perception of single-occupancy versus multioccupancy rooms in acute care environments: an ex...