Document Detail

Successful outcome with intrauterine transfusion in non-immune hydrops fetalis secondary to congenital syphilis.
MedLine Citation:
PMID:  21050519     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Congenital syphilis is rare, but the incidence has increased over the last few years in Alberta. Previous reports of fetal hydrops secondary to syphilis are few and have not demonstrated the application of middle cerebral artery peak systolic velocity (MCA PSV) to monitor for fetal anemia, or reported successful management with intrauterine transfusion.
CASE: A 17-year-old primigravida at 28 weeks' gestational age with positive syphilis serology and fetal hydrops was treated with high-dose intravenous penicillin. An elevated MCA PSV suggested fetal anemia. Successful intrauterine cordocentesis and transfusion of packed red blood cells led to resolution of fetal hydrops. The fetus delivered spontaneously at 35 weeks' gestation with no clinical signs of congenital syphilis.
CONCLUSION: Syphilitic hydrops may be successfully managed with high dose intravenous penicillin, measurement of MCA PSV, and intrauterine transfusion.
Innie Chen; Sujata Chandra; Ameeta Singh; Manoj Kumar; Venu Jain; Roger Turnell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC     Volume:  32     ISSN:  1701-2163     ISO Abbreviation:  J Obstet Gynaecol Can     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126664     Medline TA:  J Obstet Gynaecol Can     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  861-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Alberta, Edmonton AB.
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MeSH Terms
Blood Transfusion, Intrauterine*
Erythrocyte Transfusion*
Hydrops Fetalis / etiology,  therapy*
Syphilis, Congenital / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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