Document Detail


Successful outcome after antibiotic treatment of postamniocentesis membrane rupture and chorioamnionitis in multiple pregnancy.
MedLine Citation:
PMID:  10772199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postamniocentesis chorioamnionitis is usually managed with induction of labor to prevent maternal sepsis and related morbidity and mortality. We report a case of chorioamnionitis in a triplet pregnancy after midtrimester genetic amniocentesis, in which multiple antibiotic treatment (ampicillin 2 g i.v. loading dose followed by 1 g i.v. every 6 hr; clindamycin 900 mg i.v. every 8 hr; gentamicin 120 mg i.v. loading dose followed by 100 mg i.v. every 8 hrs; and erythromycin 500 mg i.v. every 6 hr) for 7 days and delivery of the presumably infected triplet A successfully reversed the clinical symptomatology, allowing prolongation of pregnancy until 26 weeks and survival of the remaining fetuses. At age 2 years, both infants are doing well and are meeting their developmental milestones. The viable outcome of this management strategy suggests that antibiotic treatment and expectancy may be an option in selected cases of postamniocentesis chorioamnionitis in multiple pregnancies.
Authors:
A Ghidini; V Doria; V Kirn; V Korker
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  16     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1999  
Date Detail:
Created Date:  2000-05-16     Completed Date:  2000-05-16     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  403-6     Citation Subset:  IM    
Affiliation:
Perinatal Diagnostic Center, Inova Alexandria Hospital, Virginia 22304, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniocentesis / adverse effects*
Ampicillin / administration & dosage
Anti-Inflammatory Agents / therapeutic use
Betamethasone / therapeutic use
Chorioamnionitis / drug therapy*,  etiology
Clindamycin / administration & dosage
Drug Administration Schedule
Drug Therapy, Combination / administration & dosage*
Erythromycin / administration & dosage
Female
Fetal Death
Fetal Membranes, Premature Rupture / drug therapy,  etiology
Gentamicins / administration & dosage
Humans
Infant, Newborn
Injections, Intravenous
Male
Oligohydramnios / drug therapy,  etiology
Pregnancy
Pregnancy Outcome*
Pregnancy Trimester, Second
Triplets*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Gentamicins; 114-07-8/Erythromycin; 18323-44-9/Clindamycin; 378-44-9/Betamethasone; 69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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