| Successful outcome after antibiotic treatment of postamniocentesis membrane rupture and chorioamnionitis in multiple pregnancy. | |
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MedLine Citation:
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PMID: 10772199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postamniocentesis chorioamnionitis is usually managed with induction of labor to prevent maternal sepsis and related morbidity and mortality. We report a case of chorioamnionitis in a triplet pregnancy after midtrimester genetic amniocentesis, in which multiple antibiotic treatment (ampicillin 2 g i.v. loading dose followed by 1 g i.v. every 6 hr; clindamycin 900 mg i.v. every 8 hr; gentamicin 120 mg i.v. loading dose followed by 100 mg i.v. every 8 hrs; and erythromycin 500 mg i.v. every 6 hr) for 7 days and delivery of the presumably infected triplet A successfully reversed the clinical symptomatology, allowing prolongation of pregnancy until 26 weeks and survival of the remaining fetuses. At age 2 years, both infants are doing well and are meeting their developmental milestones. The viable outcome of this management strategy suggests that antibiotic treatment and expectancy may be an option in selected cases of postamniocentesis chorioamnionitis in multiple pregnancies. |
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Authors:
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A Ghidini; V Doria; V Kirn; V Korker |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of perinatology Volume: 16 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 1999 |
Date Detail:
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Created Date: 2000-05-16 Completed Date: 2000-05-16 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 403-6 Citation Subset: IM |
Affiliation:
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Perinatal Diagnostic Center, Inova Alexandria Hospital, Virginia 22304, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniocentesis / adverse effects* Ampicillin / administration & dosage Anti-Inflammatory Agents / therapeutic use Betamethasone / therapeutic use Chorioamnionitis / drug therapy*, etiology Clindamycin / administration & dosage Drug Administration Schedule Drug Therapy, Combination / administration & dosage* Erythromycin / administration & dosage Female Fetal Death Fetal Membranes, Premature Rupture / drug therapy, etiology Gentamicins / administration & dosage Humans Infant, Newborn Injections, Intravenous Male Oligohydramnios / drug therapy, etiology Pregnancy Pregnancy Outcome* Pregnancy Trimester, Second Triplets* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Gentamicins; 114-07-8/Erythromycin; 18323-44-9/Clindamycin; 378-44-9/Betamethasone; 69-53-4/Ampicillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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