Document Detail


Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report.
MedLine Citation:
PMID:  17205387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a 17-year-old male with disseminated intracranial choriocarcinoma at the basal ganglia whose consciousness level was very low at diagnosis. He received neoadjuvant therapy (NAT) consisting of combined chemo- and radiotherapy prior to radical excision of the tumor. Postoperatively he was treated with three courses of high-dose chemotherapy (carboplatin (CBDCA), methotrexate (MTX), and etoposide (VP-16)) and peripheral blood stem-cell transplantation. This combination of therapies resulted in tumor regression on MRI and remarkable improvement in his neurological condition. Ours is the first report of the effectiveness of NAT followed by radical surgery in a patient with disseminated primary intracranial choriocarcinoma.
Authors:
Teruyoshi Kageji; Shinji Nagahiro; Kazuhito Matsuzaki; Yasuhiko Kanematsu; Minoru Nakatani; Yasuhiko Okamoto; Tsutomu Watanabe
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-01-05
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  83     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-16     Completed Date:  2007-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery and Pediatrics, School of Medicine, The University of Tokushima, Kuramoto-cho 3-18-15, 770, Tokushima, Japan. kageji@clin.med.tokushima-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Brain Neoplasms / blood,  drug therapy*,  radiotherapy*,  surgery
Carboplatin / administration & dosage
Choriocarcinoma / blood,  drug therapy*,  radiotherapy*,  surgery
Chorionic Gonadotropin, beta Subunit, Human / blood
Combined Modality Therapy
Etoposide / administration & dosage
Humans
Male
Methotrexate / administration & dosage
Neoadjuvant Therapy / methods*
Peripheral Blood Stem Cell Transplantation
Treatment Outcome
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; 33419-42-0/Etoposide; 41575-94-4/Carboplatin; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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