Document Detail

Successful multiple pregnancy achieved after transfer of frozen embryos obtained via intracytoplasmic sperm injection with testicular sperm from an AZFc-deleted man.
MedLine Citation:
PMID:  20447624     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe a case of successful triplet pregnancy after testicular sperm extraction (TESE) from a man with AZFc deletion and intracytoplasmic sperm injection (ICSI).
DESIGN: Case report.
SETTING: University hospital.
PATIENT(S): A 38-year-old man affected by complete AZFc deletion and azoospermia.
INTERVENTION(S): Spermiogram, Y-chromosome microdeletion screening, TESE for sperm recovery from testicular tissue on the same day as ICSI, transfer of frozen-thawed embryos, vaginal ultrasound examination.
MAIN OUTCOME MEASURE(S): The Y chromosome genetic status of an azoospermic patient who underwent TESE and ICSI, the fertilization and pregnancy outcome.
RESULT(S): The patient was found to be azoospermic, and the deletion screening showed complete AZFc deletion. After TESE, the recovered testicular sperm were selected for ICSI. Three good quality embryos were obtained and were frozen due to ovarian hyperstimulation syndrome in the female partner. After transfer of the thawed embryos, a triplet pregnancy was diagnosed by vaginal ultrasonography at the seventh week of gestation. Two male and one female healthy babies were born.
CONCLUSION(S): This is the first report of a successful triplet pregnancy after the transfer of frozen-thawed embryos in a couple in whom the male partner was azoospermic and a carrier of complete AZFc deletion. This deletion should not adversely affect a man's TESE retrieval prognosis or the fertilization, cleavage, and implantation of embryos. The offspring were healthy, although the two sons inherited the AZFc deletion.
Laura Gambera; Laura Governini; Vincenzo De Leo; Alice Luddi; Giuseppe Morgante; Valeria Tallis; Paola Piomboni
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-05-05
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-12-08     Revised Date:  2011-12-14    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2330.e1-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Center for the Diagnosis and Treatment of Couple Sterility, Siena Hospital, University of Siena, Siena, Italy.
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MeSH Terms
Azoospermia / genetics,  pathology,  therapy*
Embryo Transfer / methods*
Gene Deletion*
Genetic Loci
Pregnancy, Multiple*
Seminal Plasma Proteins / genetics*
Sperm Injections, Intracytoplasmic / methods*
Spermatozoa / metabolism,  pathology
Treatment Outcome
Reg. No./Substance:
0/Seminal Plasma Proteins

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