| Successful mobilization, harvest and transplant of peripheral blood stem cells using AMD3100 and G-CSF following high dose craniospinal irradiation for medulloblastoma in a young child. | |
| | |
MedLine Citation:
|
PMID: 19998469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Contemporary protocols for the treatment of malignant brain tumors such as medulloblastoma (MB) in children, often involve craniospinal irradiation (CSI) at diagnosis followed by serial courses of high dose chemotherapy and autologous hematopoietic stem cell support. Patients often require several pheresis procedures in order to collect sufficient stem cells for this type of treatment, particularly if they have already had CSI. We describe the successful mobilization, collection and subsequent transplant of a 7-year-old female with medulloblastoma after recent CSI using granulocyte colony stimulating factor (G-CSF) and the CXCR4 antagonist AMD3100 after a failed previous mobilization attempt using G-CSF alone. |
| | |
Authors:
|
Helen Toledano; Anat Yahel; Ian J Cohen; Isaac Yaniv; Jerry Stein |
Related Documents
:
|
10482939 - Immunological reconstitution and correlation of circulating serum inflammatory mediator... 11243399 - Purified autologous grafting in childhood acute lymphoblastic leukemia in second remiss... 7538339 - Primitive hematopoietic progenitor cells are present in peripheral blood autografts. 17369869 - Mobilizing stem cells from normal donors: is it possible to improve upon g-csf? 11122089 - Primitive haematopoietic progenitors in the blood of patients with sickle cell disease ... 11108299 - Increased stem cell dose, as obtained using currently available technology, may not be ... 11118039 - Neutral endopeptidase promotes phorbol ester-induced apoptosis in prostate cancer cells... 1696539 - Flow cytometric method to monitor the destruction of cd4+ cells following their fusion ... 10362149 - Cytotoxicity with auger electron-emitting radionuclides delivered by antibodies. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Pediatric blood & cancer Volume: 54 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-02-17 Completed Date: 2010-04-19 Revised Date: 2010-09-07 |
Medline Journal Info:
|
Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 613-5 Citation Subset: IM |
Affiliation:
|
Department of Pediatric Hematology Oncology, Petach Tikva, Israel. helent@clalit.org.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adjuvants, Immunologic
/
therapeutic use Antineoplastic Agents / therapeutic use Cerebellar Neoplasms / therapy* Child Cisplatin / therapeutic use Combined Modality Therapy Cranial Irradiation Female Granulocyte Colony-Stimulating Factor / therapeutic use* Hematopoietic Stem Cell Mobilization / methods* Heterocyclic Compounds / therapeutic use* Humans Medulloblastoma / therapy* Peripheral Blood Stem Cell Transplantation / methods* Receptors, CXCR4 / antagonists & inhibitors, drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Adjuvants, Immunologic; 0/Antineoplastic Agents; 0/CXCR4 protein, human; 0/Heterocyclic Compounds; 0/Receptors, CXCR4; 143011-72-7/Granulocyte Colony-Stimulating Factor; 155148-31-5/JM 3100; 15663-27-1/Cisplatin |
| Comments/Corrections | |
Comment In:
|
Pediatr Blood Cancer. 2010 Oct;55(4):769
[PMID:
20806370
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pseudometastasis secondary to histoplasmosis infection: False-positive PET/CT findings.
Next Document: Thiotepa/topotecan/carboplatin with autologous stem cell rescue in recurrent/refractory/poor prognos...