Document Detail

Successful medical management of renal zygomycosis: a summary of two cases and a review of the Indian literature.
MedLine Citation:
PMID:  20367111     Owner:  NLM     Status:  MEDLINE    
We present two cases of renal zygomycosis caused by Apophysomyces elegans and Mycocladus corymbifer in previously healthy immunocompetent males and an overview of the disease in India. In both cases a percutaneous nephrostomy (PCN) was performed and the etiologic agents were identified by direct microscopy and culture. Amphotericin B was administered and both patients recovered completely. A review of the literature revealed 42 cases of renal zygomycosis in India. The majority of them were from the Postgraduate Institute of Medical Education and Research, Chandigarh, in North India. In contrast to cases from the developed world where transplant recipients and patients with hematological malignancies seem to be most vulnerable to zygomycosis, the most common risk factor in India is uncontrolled diabetes mellitus. However, renal zygomycosis is an exception and the patients in both of our cases had no identifiable underlying disorder and recovered successfully without nephrectomy. It is important to emphasize that treatment of A. elegans must be aggressive and lipid formulations of antifungals are typically favored due to their limited side effects profile and ability of the clinician to use higher doses. A high index of clinical suspicion and knowledge of the varied manifestations in diagnosing this condition cannot be overemphasized.
Rungmei S K Marak; Richa Misra; M S Ansari; Ajai Dixit; Poornima; K N Prasad; T N Dhole
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-04-01
Journal Detail:
Title:  Medical mycology     Volume:  48     ISSN:  1460-2709     ISO Abbreviation:  Med. Mycol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-02-25     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1088-95     Citation Subset:  IM    
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MeSH Terms
Amphotericin B / administration & dosage
Antifungal Agents / administration & dosage
Kidney Diseases / drug therapy*,  microbiology,  surgery*
Mucorales / classification,  isolation & purification*
Mycology / methods
Nephrostomy, Percutaneous
Treatment Outcome
Zygomycosis / drug therapy*
Reg. No./Substance:
0/Antifungal Agents; 7XU7A7DROE/Amphotericin B

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