Document Detail


Successful management with octreotide of a child with L-asparaginase induced hemorrhagic pancreatitis.
MedLine Citation:
PMID:  9403019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Octreotide is a synthetic somatostatin analogue which has been suggested for use in the management of acute pancreatitis. While studies have looked at octreotide use in the setting of pancreatitis due to chronic alcohol use or trauma, little is known of its role in management of drug induced acute pancreatitis; particularly in the pediatric setting. PATIENTS AND METHODS: We present a case of a 5 1/2-year-old white female who developed severe, necrotizing, hemorrhagic pancreatitis with pseudocyst formation secondary to L-asparaginase use as a part of her therapy for acute lymphoblastic leukemia (ALL). She was managed initially with intravenous fluids, bowel rest, nasogastric suctioning, parenteral narcotices, and broad spectrum antibiotics. In addition, within 12 hours of admission to The Children's Hospital (TCH) in Denver, Colorado, she began therapy with octreotide (5 micrograms/kg/day IV divided b.i.d.). With this management, her pseudocyst decompressed without need for surgical intervention, her pancreatitis fully resolved, and she recovered full pancreatic function without any long-term sequelae. CONCLUSION: Use of octreotide may have served a role in limiting the severity of the disease process in this case. Further studies need to be done to verify its usefulness in this setting.
Authors:
T Garrington; D Bensard; J D Ingram; C C Silliman
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medical and pediatric oncology     Volume:  30     ISSN:  0098-1532     ISO Abbreviation:  Med. Pediatr. Oncol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1997-12-31     Completed Date:  1997-12-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7506654     Medline TA:  Med Pediatr Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  106-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Colorado School of Medicine, Denver, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Asparaginase / adverse effects*
Child, Preschool
Female
Humans
Octreotide / therapeutic use*
Pancreatitis / chemically induced,  drug therapy*
Grant Support
ID/Acronym/Agency:
M01-RR00069/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
83150-76-9/Octreotide; EC 3.5.1.1/Asparaginase
Comments/Corrections
Comment In:
Med Pediatr Oncol. 1998 Aug;31(2):127   [PMID:  9714616 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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