Document Detail

Successful management of systemic lupus erythematosus nephritis flare-up during pregnancy with tacrolimus.
MedLine Citation:
PMID:  20680376     Owner:  NLM     Status:  In-Data-Review    
Systemic lupus erythematosus (SLE) is one of the common autoimmune disorders that affect women during their childbearing years. Disease activity frequently increases during pregnancy and the postpartum period, representing a challenge for both the patient and the treating physician(s). We report a case of successful management of lupus nephritis flare in the first trimester. The patient developed bilateral leg edema and nephrotic-range proteinuria of 5 g/day. She was treated with steroids and tacrolimus, which resulted in the induction of remission during pregnancy. The patient reached full-term with no maternal or fetal complications. This case indicates that tacrolimus, which is convenient to use and has limited adverse effects, may represent a potential safe and effective treatment option for SLE nephritis during pregnancy.
Abdulkareem Alsuwaida
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Publication Detail:
Type:  Journal Article     Date:  2010-08-04
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  21     ISSN:  1439-7609     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  73-5     Citation Subset:  IM    
Department of Medicine, King Saud University, P.O. Box 2925, Riyadh, 11321, Saudi Arabia,
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