| Successful management of steroid-resistant nephrotic syndrome using ibuprofen. | |
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MedLine Citation:
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PMID: 9021245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the first case of the use of ibuprofen for the management of steroid-resistant nephrotic syndrome. A 41 year-old man with nephrotic syndrome, secondary to focal segmental glomerulosclerosis, had persistent nephrotic range proteinuria despite aggressive treatment with steroids and cyclophosphamide. His steroid-resistant nephrotic syndrome resolved rapidly when he was serendipituously started on ibuprofen for the treatment of pericarditis. His proteinuria remained low at about 0.5 g/day over the next two years of treatment with ibuprofen and without any increase in his serum creatinine. He did not receive any ACE inhibitor or calcium channel blocker. An attempt to discontinue ibuprofen resulted in the relapse of his nephrotic syndrome. Upon restarting ibuprofen, his proteinuria decreased to less than 0.5 g/day again. We conclude that ibuprofen has been effective and safe for the management of nephrotic syndrome in this patient. However, careful monitoring is prudent to assess the potential adverse effects of ibuprofen on renal function with prolonged use. |
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Authors:
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C L Low; M D McGoldrick; G R Bailie |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical nephrology Volume: 47 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-04-14 Completed Date: 1997-04-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 60-2 Citation Subset: IM |
Affiliation:
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Albany College of Pharmacy, NY 12208, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Anti-Inflammatory Agents, Non-Steroidal / therapeutic use* Biopsy Cyclophosphamide / therapeutic use Drug Resistance Drug Therapy, Combination Follow-Up Studies Glucocorticoids / therapeutic use* Humans Ibuprofen / therapeutic use* Immunosuppressive Agents / therapeutic use Male Nephrotic Syndrome / drug therapy*, pathology Prednisone / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Glucocorticoids; 0/Immunosuppressive Agents; 15687-27-1/Ibuprofen; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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