Document Detail

Successful management of a retroperitoneal kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon using alpha-interferon.
MedLine Citation:
PMID:  17160787     Owner:  NLM     Status:  MEDLINE    
It has been shown recently that Kasabach-Merritt phenomenon, the association of a vascular tumour and consumption coagulopathy, does not--as previously thought--complicate "classical" infantile hemangiomas but distinctive entities called kaposiform hemangioendothelioma (KHE) and tufted angioma (TA), both tumours on the same neoplastic spectrum. These tumours have been found in the neck, face, thorax, abdomen, retroperitoneum and limbs and are associated with a mortality rate of as high as 30 %. Several therapeutic modalities, including alpha-interferon, vincristine, radiotherapy and surgery have been reported in the literature. We report a case of retroperitoneal kaposiform hemangioendothelioma regression using alpha-interferon and discuss the current knowledge of this entity and its treatment.
L Harper; J L Michel; O Enjolras; N Raynaud-Mounet; J P Rivière; T Heigele; S De Napoli-Cocci
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie     Volume:  16     ISSN:  0939-7248     ISO Abbreviation:  Eur J Pediatr Surg     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105263     Medline TA:  Eur J Pediatr Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  369-72     Citation Subset:  IM    
Department of Paediatric Surgery, Hôpital Félix Guyon, Saint-Denis de La Réunion, France.
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MeSH Terms
Angiogenesis Inhibitors / administration & dosage,  therapeutic use*
Disseminated Intravascular Coagulation / etiology
Hemangioendothelioma / complications,  drug therapy*
Interferon-alpha / administration & dosage,  therapeutic use*
Platelet Count
Thrombocytopenia / etiology
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Interferon-alpha

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