| Successful management of pregnancy with nephrotic syndrome due to preexisting membranous glomerulonephritis: a case report. | |
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MedLine Citation:
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PMID: 18753755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of membranous glomerulonephritis (MGN) on maternal and fetal outcome is controversial, as is the effect of pregnancy on the course of preexisting nephrotic syndrome. We report a case of successful management of a pregnancy with preexisting severe nephrotic syndrome due to biopsy-proven primary MGN. Our patient became pregnant in a non-compliance period, discontinued the nephrological follow-up program and her kidney disease decompensated. From the 22nd gestational week the patient was treated with intermittent pulses of methylprednisolone (250 mg i.v.) and a maintenance dose of 32-64 mg/day orally, along with azathioprine 100 mg/day. She also received antihypertensive, diuretic, and anticoagulant therapy, and supplementation with fresh frozen plasma and albumin. In the 33rd gestational week a cesarean section was performed due to deteriorating creatinine clearance, low serum total protein levels, increasing edema and progression of intrauterine growth retardation of the fetus. Three months after delivery, the patient's renal disease went into complete remission. To our knowledge, this is the first report of using azathioprine during pregnancy with severe nephrotic syndrome due to primary MGN. |
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Authors:
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Andras Sebestyen; Szabolcs Varbiro; Levente Sara; Gyorgy Deak; Lorant Kerkovits; Istvan Szabo; Istvan Kiss; Ferenc Paulin |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-08-28 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 24 ISSN: 1421-9964 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-21 Completed Date: 2009-01-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 186-9 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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Faculty of Medicine, Semmelweis University, Budapest, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Glomerulonephritis, Membranous / complications* Humans Nephrotic Syndrome / complications, etiology*, therapy Pregnancy Pregnancy Complications / therapy* Treatment Outcome |
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