Document Detail

Successful management of pregnancy in a patient with eisenmenger syndrome with epoprostenol.
MedLine Citation:
PMID:  12970054     Owner:  NLM     Status:  MEDLINE    
Pregnancy in the setting of pulmonary hypertension and Eisenmenger physiology is associated with a substantial maternal and fetal risk. Such patients are advised against pregnancy. We report a case of a woman with an Eisenmenger atrial septal defect diagnosed during the last trimester of pregnancy. On presentation, she was critically ill and there was evidence of fetal distress. She was emergently treated with IV epoprostenol, and her status improved. She underwent cesarean section and delivered a male infant with Apgar scores of 8 and 9. Her dyspnea improved, and she was characterized as World Health Organization functional class II on a subsequent clinical visit. Although pregnancy should be discouraged in women with Eisenmenger syndrome, we have demonstrated that IV epoprostenol successfully treated a woman with Eisenmenger syndrome diagnosed in the third trimester.
Chris Geohas; Vallerie V McLaughlin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  124     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-12     Completed Date:  2003-10-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1170-3     Citation Subset:  AIM; IM    
Division of Cardiology, Rush-Presbyterian-St. Luke's Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Cesarean Section
Critical Illness
Echocardiography, Doppler, Color
Eisenmenger Complex / drug therapy*,  ultrasonography
Electrocardiography / drug effects
Epoprostenol / therapeutic use*
Fetal Distress / drug therapy,  etiology
Heart Septal Defects, Atrial / drug therapy,  ultrasonography
Hemodynamics / drug effects
Infant, Newborn
Infusions, Intravenous
Pregnancy Complications, Cardiovascular / drug therapy*,  ultrasonography
Reg. No./Substance:
0/Antihypertensive Agents; 35121-78-9/Epoprostenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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