Document Detail


Successful management and perinatal outcome of pregnancy complicated with myelodysplastic syndrome.
MedLine Citation:
PMID:  11792414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy complicated with myelodysplastic syndrome (MDS) is rare and case management is controversial. We report six cases of MDS that were successfully managed during pregnancy including uneventful transvaginal delivery and satisfactory postpartum clinical prognosis. Two patients with MDS who became pregnant twice had normal uneventful deliveries showing no deterioration of MDS. Our findings suggest that pregnancy should be allowed to full-term in MDS patients, especially those of the refractory anemia type, but strict management should be provided before, during and after pregnancy. Pancytopenia might develop during pregnancy but the likelihood of transformation of MDS to leukemia due to pregnancy is remote.
Authors:
Yuichiro Ikeda; Hideaki Masuzaki; Daisuke Nakayama; Takahiro Maeda; Khaleque Newaz Khan; Yuko Okita; Emiko Doi; Masao Tomonaga; Tadayuki Ishimaru
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia research     Volume:  26     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-01-16     Completed Date:  2002-05-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
Affiliation:
Departments of Obstetrics and Gynecology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. ikebon@net.nagasaki-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / genetics,  pathology,  therapy
Anemia, Refractory, with Excess of Blasts / genetics,  therapy
Bone Marrow / pathology
Delivery, Obstetric
Diagnosis, Differential
Female
Follow-Up Studies
Humans
Infant, Newborn
Karyotyping
Myelodysplastic Syndromes / genetics,  pathology,  therapy*
Pregnancy
Pregnancy Complications / pathology,  therapy*
Pregnancy Outcome*
Prognosis
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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