Document Detail

Successful living related liver transplantation in a case with biliary atresia associated with corrected transposition of the great arteries.
MedLine Citation:
PMID:  17631024     Owner:  NLM     Status:  MEDLINE    
Little is known about the safety of LRLTx in children with end stage liver disease associated with congenital cardiac anomalies. We report the successful LRLTx in a case with extrahepatic biliary atresia associated with cTGA, VSD, and PS. Preoperative cardiac function was evaluated by cardiac echogram and cardiac catheterization. The recipient's cardiac function was preserved (EF; 54%); however, because of the left to right shunt disease, oxygen saturation was 91%. At operation, carbon dioxide insufflation into the abdominal cavity was attempted to prevent sudden air embolism. Hemodynamic variables were stabilized during partial clamping of the inferior vena cava, and at reperfusion of the portal vein. However, a sudden decrease in blood oxygenation was observed during hepatico-jejunostomy, which was easily normalized by graft mobilization. Post-operatively, neither heart failure nor cerebral infarction because of air embolism was observed. In conclusion, together with preserved cardiac function and carbon dioxide insufflation, LRLTx was successful. Further studies are required to establish the algorithm for the strategy of treating both congenital cardiac anomalies and liver failure.
Takuya Kimura; Toshimichi Hasegawa; Yoshiyuki Ihara; Sotaro Mushiake; Shigetoyo Kogaki; Keizo Dono; Masahiro Fukuzawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric transplantation     Volume:  11     ISSN:  1397-3142     ISO Abbreviation:  Pediatr Transplant     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802574     Medline TA:  Pediatr Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  540-2     Citation Subset:  IM    
Division of Pediatric Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
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MeSH Terms
Biliary Atresia / complications*
Cardiac Surgical Procedures
Child, Preschool
Follow-Up Studies
Liver Failure / etiology,  surgery*
Liver Transplantation / methods*
Time Factors
Transposition of Great Vessels / complications*,  surgery
Comment In:
Pediatr Transplant. 2007 Aug;11(5):461-2   [PMID:  17631011 ]

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