| Successful live birth from vitrified oocytes after 5 years of cryopreservation. | |
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MedLine Citation:
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PMID: 20886366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a birth of a healthy boy after long-term cryopreservation of oocytes by vitrification. DESIGN: Clinical application. SETTING: IVF Center. PATIENT: A 17 year-old female with secondary pulmonary hypertension caused by transposition of great vessels visited our center in 2002, and she wished oocytes cryopreservation to avoid possible sterility after the following category X medication treatment. INTERVENTION(S): Vitrified oocytes on Electron Microscope (EM) grids were warmed after 5 years of storage. Surviving MII oocytes were microinjected for fertilization and two embryos were transferred into a gestational carrier day 5 after microinjection. MAIN OUTCOME MEASURE(S): Survival, fertilization, cleavage, clinical pregnancy and delivery. RESULT(S): Eleven out of fourteen oocytes (78.6%) survived warming. Eight Metaphase II (MII) oocytes and 3 in vitro matured oocytes were microinjected; all 11 oocytes (100%) fertilized and 2 embryos were transferred on day 5. A healthy baby boy weighing 3,600 g was delivered at 38 weeks of gestation. Live-birth rates per warmed oocyte and per injected oocyte were 7.1% and 9.1% respectively. CONCLUSION(S): Cryopreservation after vitrification with EM grids maintained the developmental competence of oocytes after long-term storage and resulted in a successful live birth. |
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Authors:
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Thomas J Kim; Seung Wook Hong |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-10-01 |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 28 ISSN: 1573-7330 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-03-01 Completed Date: 2011-06-13 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: Netherlands |
Other Details:
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Languages: eng Pagination: 73-6 Citation Subset: IM |
Affiliation:
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Reproductive Medicine Associates of New Jersey, Morristown, NJ, 07960, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Cryopreservation* Embryo Transfer Embryonic Development Female Fertilization in Vitro Humans Infant Live Birth* Male Metaphase Oocytes / growth & development* Pregnancy Time Factors Treatment Outcome Vitrification* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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