Document Detail

Successful left hemihepatectomy and perioperative management of a patient with biliary cystadenocarcinoma, complicated with MELAS syndrome: report of a case.
MedLine Citation:
PMID:  20740354     Owner:  NLM     Status:  MEDLINE    
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like syndrome (MELAS) is a rare, fetal disease caused by a mutation in mitochondrial DNA that leads to impaired oxidative metabolism in skeletal muscle, the central nervous system, and liver function. This report presents the case of a 50-year-old woman with biliary cystadenocarcinoma complicated by MELAS who underwent a successful left hemihepatectomy. In this case, the diagnostic key for the malignant tumor was an (18)F-fluorodeoxyglucose positron emission tomography study, which was useful even in a patient with MELAS, which causes abnormal glucose metabolism. The perioperative management of such patients includes special precautions to prevent lactic acidosis and deterioration of the reserved liver function after a hepatectomy, since the mitochondrial function in MELAS patients is abnormal. The patient in this report has remained free of liver dysfunctions and cancer recurrence for 2 years following the hepatectomy. This is the first report of a successful major hepatectomy for a patient with MELAS.
Ayami Ohno; Akira Mori; Ryuichiro Doi; Yoshikuni Yonenaga; Noboru Asano; Shinji Uemoto
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-08-26
Journal Detail:
Title:  Surgery today     Volume:  40     ISSN:  1436-2813     ISO Abbreviation:  Surg. Today     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-26     Completed Date:  2011-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  878-82     Citation Subset:  IM    
Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
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MeSH Terms
Biliary Tract Neoplasms / complications,  radionuclide imaging,  surgery*
Cystadenocarcinoma / complications,  radionuclide imaging,  surgery*
MELAS Syndrome / complications*
Middle Aged
Perioperative Care*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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