Document Detail

Successful islet transplantation in spontaneous diabetes.
MedLine Citation:
PMID:  223249     Owner:  NLM     Status:  MEDLINE    
Optimism for islet transplantation is based on reversal of diabetes artificially induced in animals by pancreatectomy or beta cell toxins. In naturally occurring diabetes, implanted islets might be destroyed by the etiologic agent of the original disease; e.g., virus infection, genetic factors, or autoimmunity. Genetically determined diabetes in obese mice, in fact, is resistant to islet transplantation. Since these mice are hyperinsulinemic and not similar to human juvenile onset diabetes (JOD), more appropriate models were sought, "BB" rats spontaneously develop a syndrome remarkably similar to human JOD. We have studied 279 BB rats. In 31 rats the sudden onset of severe hyperglycemia was observed. Sinc BB rats proved to be AgB2 on serological typing, WF (AgB2) donors were selected. Six hundred Wistar-Furth isolated islets were transplanted intraportally in 10 BB diabetic rats immunosuppressed with antilymphocyte serum. All 10 recipients became normoglycemic, remaining so for 1 to 6 monts. An additional animal model studied was virus-induced diabetes in mice, since viral etiology of human diabetes seems likely. DBA mice receiving encephalomyocarditis virus became severely and persistently diabetic. Eight received syngeneic fetal pancreas to the renal subcapsule and became normoglycemic. Removal of the graft 30 days later demonstrated viable islets histologically and resulted in recurrent diabetes. That virally induced murine diabetes and one spontaneous syndrome in rats which is similar to human JOD responded to beta cell implantation argues that this treatment will be effective in man.
A Naji; W K Silvers; S A Plotkin; D Dafoe; C F Barker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  86     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  218-26     Citation Subset:  AIM; IM    
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MeSH Terms
Animals, Newborn
Antilymphocyte Serum / pharmacology
Blood Glucose / analysis
Diabetes Mellitus, Experimental / etiology,  therapy*
Disease Models, Animal
Encephalomyocarditis virus
Enterovirus Infections / complications
Islets of Langerhans Transplantation*
Kidney / surgery
Mice, Inbred C57BL
Mice, Inbred DBA
Portal Vein
Rats, Inbred Strains
Time Factors
Transplantation, Homologous
Reg. No./Substance:
0/Antilymphocyte Serum; 0/Blood Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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