| Successful intrathecal ethanol block for intractable spasticity of AIDS-related progressive multifocal leukoencephalopathy. | |
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MedLine Citation:
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PMID: 10432267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the efficacy of intrathecal ethanol block to relieve intractable spasticity in AIDS-related progressive multifocal leukoencephalopathy (PML) when long-term intrathecal baclofen infusion cannot be used. METHODS: A 33-year-old man with AIDS-related PML developed very severe spastic paraparesis (Ashworth rigidity score, 4) and painful muscle spasms. The patient was unable to sit in his wheelchair and remained bed bound. Combined oral baclofen and tizanidine at therapeutical doses were used without any effect on the spasticity. The patient refused the placement of an intrathecal catheter for long-term baclofen infusion. A single intrathecal ethanol (6 ml) injection in the L2-L3 intervertebral space with the patient placed in a lateral Trendelenburg (40 C) position was performed. RESULTS: The procedure was very effective in improving the stiffness (Ashworth rigidity score. 2, after the technique) and the muscle spasms disappeared. No side effects during or after the injection were observed. CONCLUSION: Intrathecal ethanol block is a last but very useful choice for treatment of intractable spasticity in PML and other neurologic disorders in AIDS patients when other oral treatments have failed and intrathecal baclofen infusion is not suitable. |
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Authors:
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V Asensi; J M Asensi; J A Carton; J A Maradona; M Oña; C Aréchaga |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Spinal cord Volume: 37 ISSN: 1362-4393 ISO Abbreviation: Spinal Cord Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-10-05 Completed Date: 1999-10-05 Revised Date: 2011-06-06 |
Medline Journal Info:
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Nlm Unique ID: 9609749 Medline TA: Spinal Cord Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 450-2 Citation Subset: IM; X |
Affiliation:
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Infectious Diseases Unit, Hospital Central de Asturias, Oviedo University Medical School, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications* Adult Ethanol / therapeutic use* Humans Injections, Spinal Leukoencephalopathy, Progressive Multifocal / complications* Male Muscle Spasticity / drug therapy*, etiology |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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