Document Detail

Successful intra-arterial thrombolytic therapy for a right middle cerebral artery stroke in a 2-year-old supported by a ventricular assist device.
MedLine Citation:
PMID:  22211986     Owner:  NLM     Status:  Publisher    
Embolic stroke is a common complication in patients on ventricular assist devices in both adults and children. The reported incidence of strokes in children supported by VAD's varies from 7 to 38%. The rapid increase in recent years in the availability of both adult and pediatric VADs will likely add to the overall prevalence of strokes in patients being bridged to heart transplant. Strokes in this population can be lethal as they frequently necessitate withdrawal of the extracorporeal device support and withdrawal from the organ transplant waiting list. We present a case of a fully anti-coagulated 29-month-old supported on a Berlin EXCOR LVAD (Berlin, Germany) with embolic stroke which was treated successfully with direct thrombolysis with recombinant tissue plasminogen activator. This is the first report which uses intra-arterial thrombolytics while on a ventricular assist device in a pediatric patient.
Jonathan W Byrnes; Blake Williams; Parthak Prodhan; Eren Erdem; Charles James; Randy Williamson; Nischal Gautam; Michiaki Imamura; Robert Jaquiss; Adnan Bhutta
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-27
Journal Detail:
Title:  Transplant international : official journal of the European Society for Organ Transplantation     Volume:  -     ISSN:  1432-2277     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908516     Medline TA:  Transpl Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Transplant International © 2011 European Society for Organ Transplantation.
 Department of Pediatrics, University of Arkansas Medical Sciences, Little Rock, AR, USA  School of Medicine, University of Arkansas Medical Sciences, Little Rock, AR, USA  Department of Radiology, University of Arkansas Medical Sciences, Little Rock, AR, USA  Department of Anesthesiology, University of Arkansas Medical Sciences, Little Rock, AR, USA  Department of Surgery, University of Arkansas Medical Sciences, Little Rock, AR, USA.
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