| Successful implementation of cooperative handling eliminates the need for restraint in a complex non-human primate disease model. | |
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MedLine Citation:
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PMID: 22150842 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background Streptozotocin-induced diabetic non-human primates are used to study efficacy and safety of innovative immunosuppression after islet transplantation. We implemented a training program for medical management of a chronic disease state. Methods Cooperation with hand feeding and drinking, shifting, and limb presentation were trained utilizing predominately positive but also negative reinforcement in 52 animals compared with 28 macaques subjected to conventional physical and/or chemical restraint. The success and timing of behavior acquisition was evaluated in a representative subset of 14 animals. Results Over 90% of animals were successful in behavior acquisition. Programmatically this resulted in complete elimination of chair restraint and negligible requirement for sedation. About half of the trained animals had no-to-moderate thymic involution, indicative of a substantial reduction in stress. Conclusion Cooperative handling enhances animal well-being. This contributes to validity of scientific results and eliminates model-induced confounding that can obstruct interpretation of safety and efficacy data. |
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Authors:
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Melanie L Graham; Eric F Rieke; Lucas A Mutch; Elizabeth K Zolondek; Aaron W Faig; Theresa A Dufour; James W Munson; Jessica A Kittredge; Henk-Jan Schuurman |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
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Title: Journal of medical primatology Volume: - ISSN: 1600-0684 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0320626 Medline TA: J Med Primatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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