Document Detail

Successful immunoglobulin treatment for fulminant myocarditis and serial analysis of serum thioredoxin: a case report.
MedLine Citation:
PMID:  12381097     Owner:  NLM     Status:  MEDLINE    
A 31-year-old woman suspected to have acute myocarditis was admitted to hospital and was managed with intra-aortic balloon pumping and a percutaneous cardiopulmonary support system because of sustained ventricular tachycardia. After immunoglobulin treatment, cardiac function and systematic inflammation were improved. The left ventricular endomyocardial biopsy revealed massive necrosis and degeneration of myocardial cells, and extensive infiltration of inflammatory cells. The clinicopathology of this patient was thought to be fulminant myocarditis. Serial serum thioredoxin (TRX) analysis showed that the serum level was high during the acute phase, and decreased during the chronic phase. Immunohistochemistry for TRX in the biopsy samples showed that inflammatory cells and cardiomyocytes were positively stained.
Keisuke Shioji; Yasushi Matsuura; Tomoyuki Iwase; Shouji Kitaguchi; Hajime Nakamura; Junji Yodoi; Tetsuo Hashimoto; Chuichi Kawai; Chiharu Kishimoto
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  66     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-16     Completed Date:  2003-06-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  977-80     Citation Subset:  IM    
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan.
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MeSH Terms
Acute Disease
Angioplasty, Transluminal, Percutaneous Coronary
Immunoglobulins, Intravenous / therapeutic use*
Myocarditis / complications,  diagnosis,  drug therapy*
Myocardium / chemistry,  pathology
Tachycardia, Ventricular / etiology
Thioredoxins / analysis,  blood*
Treatment Outcome
Reg. No./Substance:
0/Immunoglobulins, Intravenous; 52500-60-4/Thioredoxins

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