| Successful extracorporeal life support in a case of severe flecainide intoxication. | |
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MedLine Citation:
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PMID: 11373489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To show the effectiveness of emergency extracorporeal membrane oxygenation (ECMO) in treating severe, life-threatening flecainide intoxication. DESIGN: Case report. SETTING: Intensive care unit in a quaternary care center. PATIENT: A patient with electromechanical dissociation after severe flecainide acetate overdose. INTERVENTION: ECMO. CASE REPORT: A 30-yr-old male with a history of depression presented after a severe flecainide overdose with plasma concentrations exceeding 20 times the upper boundary of the therapeutic range. At presentation, the patient was in refractory cardiocirculatory collapse and was successfully resuscitated with ECMO. Twenty-six hours later, extracorporeal support could be discontinued and the patient made a full recovery. CONCLUSION: In patients with severe but potentially reversible cardiac dysfunction attributable to flecainide intoxication, ECMO can maintain cardiac output and vital organ perfusion while allowing time for drug redistribution, metabolism, and clearance. |
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Authors:
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G M Auzinger; C D Scheinkestel |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Critical care medicine Volume: 29 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-05-24 Completed Date: 2001-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 887-90 Citation Subset: AIM; IM |
Affiliation:
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Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Prahran, Melbourne, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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drug therapy Adult Anti-Arrhythmia Agents / blood, poisoning* Electrocardiography Epinephrine / therapeutic use Extracorporeal Membrane Oxygenation* Flecainide / blood, poisoning* Humans Male Overdose Respiration, Artificial Sodium Bicarbonate / therapeutic use Suicide, Attempted Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 144-55-8/Sodium Bicarbonate; 51-43-4/Epinephrine; 54143-55-4/Flecainide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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