Document Detail

Successful extracorporeal life support in a case of severe flecainide intoxication.
MedLine Citation:
PMID:  11373489     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To show the effectiveness of emergency extracorporeal membrane oxygenation (ECMO) in treating severe, life-threatening flecainide intoxication. DESIGN: Case report. SETTING: Intensive care unit in a quaternary care center. PATIENT: A patient with electromechanical dissociation after severe flecainide acetate overdose. INTERVENTION: ECMO. CASE REPORT: A 30-yr-old male with a history of depression presented after a severe flecainide overdose with plasma concentrations exceeding 20 times the upper boundary of the therapeutic range. At presentation, the patient was in refractory cardiocirculatory collapse and was successfully resuscitated with ECMO. Twenty-six hours later, extracorporeal support could be discontinued and the patient made a full recovery. CONCLUSION: In patients with severe but potentially reversible cardiac dysfunction attributable to flecainide intoxication, ECMO can maintain cardiac output and vital organ perfusion while allowing time for drug redistribution, metabolism, and clearance.
G M Auzinger; C D Scheinkestel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  29     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-24     Completed Date:  2001-06-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  887-90     Citation Subset:  AIM; IM    
Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Prahran, Melbourne, Australia.
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MeSH Terms
Acidosis / drug therapy
Anti-Arrhythmia Agents / blood,  poisoning*
Epinephrine / therapeutic use
Extracorporeal Membrane Oxygenation*
Flecainide / blood,  poisoning*
Respiration, Artificial
Sodium Bicarbonate / therapeutic use
Suicide, Attempted
Treatment Outcome
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 144-55-8/Sodium Bicarbonate; 51-43-4/Epinephrine; 54143-55-4/Flecainide

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