| Successful eradication of a FVIII inhibitor in a 60-year-old patient with mild haemophilia A using single-agent prednisolone. | |
| | |
MedLine Citation:
|
PMID: 22960877 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background: Development of FVIII inhibitors represents a major challenge in patients with mild haemophilia A (HA), because they tend to occur at an older age and classical immune tolerance induction appears to be less effective. Case report: A man (age: 60 years) with mild HA due to the missense mutation, Leu1929Arg, received a single dose of rFVIII at 35IU/kg prior to routine colonoscopy, totalling 25 lifetime exposure days. Two months later, rFVIII was infused for a traumatic hip haematoma. However, FVIII recovery was inappropriate, and a FVIII inhibitor of 19 BU with type-2 kinetics was detected, resulting in FVIII:C of <1%. Two weeks later, the patient experienced spontaneous iliopsoas bleeding. Parallel to bypassing therapy, we started single-agent immunosuppression with prednisolone at 1.5mg/kg. FVIII:C "normalized" at 10.2% after four weeks. After five months, the inhibitor titre fell to <0.4BU with sustained remission after one year of follow-up. Conclusion: In mild HA, FVIII inhibitors may share characteristic features with FVIII autoantibodies commonly observed in acquired HA. Therefore, immunosuppressive therapy alone could be successful at least in a subset of patients. |
| | |
Authors:
|
K Holstein; G Marx; B Lentz; C Bokemeyer; F Langer |
Related Documents
:
|
3702567 - Composite hyoid-sternohyoid interposition graft revisited: ucla experience 1974-1984. 10917987 - A prospective randomized trial comparing vein with polytetrafluoroethylene in above-kne... 23397597 - Clinical, dermoscopic and immunohistochemical assessment of actinic keratoses and evalu... 8760987 - Angioscopically-assisted in situ saphenous vein bypass for infrainguinal revascularisat... 3335097 - Local delivery of antibiotics via an implantable pump in the treatment of osteomyelitis. 19965097 - Predication of reflex recovery after stroke using quantitative assessments of motor imp... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hämostaseologie Volume: 32 Suppl 1 ISSN: 0720-9355 ISO Abbreviation: Hamostaseologie Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-09-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8204531 Medline TA: Hamostaseologie Country: Germany |
Other Details:
|
Languages: eng Pagination: S48-51 Citation Subset: IM |
Affiliation:
|
Dr. Katharina Holstein, Gerinnungsambulanz und Hämophiliezentrum, II. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany, Tel. +49/(0)40/741052453, Fax +49/(0)40/741055193, E-mail: k.holstein@uke.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Silk fibroin hydrolysate inhibits osteoclastogenesis and induces apoptosis of osteoclasts derived fr...
Next Document: Chitosan/poly(DL,lactide-co-glycolide) scaffolds for tissue engineering.