Document Detail

Successful eculizumab treatment for multiple coronary thrombosis complicated in paroxysmal nocturnal hemoglobinuria.
MedLine Citation:
PMID:  25186487     Owner:  NLM     Status:  In-Data-Review    
We herein report a rare case of paroxysmal nocturnal hemoglobinuria (PNH) who repeatedly developed coronary arterial thromboembolism. Anticoagulant therapies including heparin, aspirin as an antiplatelet agent and even drug-eluting stent placement in the coronary artery failed to prevent the recurrence of ischemic heart disease. Of note, initiating the administration of a humanized anti-C5 antibody, eculizumab, achieved prompt thrombolysis and maintenance treatment with eculizumab prevented the recurrence of thromboembolic disease in this patient. Taking these observations together, we suggest that the use of eculizumab be considered for treatment or prevention of arterial thrombosis complicated by PNH, although arterial thrombosis is an extremely rare event in the Japanese population.
Ayuko Taniguchi; Takayuki Ikezoe; Asako Takeuchi; Kazuto Togitani; Mitsuhiro Yoshimoto; Katsutoshi Tanioka; Hiroaki Kitaoka; Akihito Yokoyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  [Rinshō ketsueki] The Japanese journal of clinical hematology     Volume:  55     ISSN:  0485-1439     ISO Abbreviation:  Rinsho Ketsueki     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-09-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984782R     Medline TA:  Rinsho Ketsueki     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  965-9     Citation Subset:  IM    
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