| Successful dexamethasone pulse therapy in a toxic epidermal necrolysis (TEN) patient featuring recurrent TEN to oxazepam. | |
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MedLine Citation:
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PMID: 11722448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 62-year-old female patient is described who developed toxic epidermal necrolysis (TEN) after medication with phenytoin and oxazepam. Initially phenytoin was discontinued and dexamethasone pulse therapy (1.5 mg/kg on 3 consecutive days) was initiated on the tenth day of skin disease. This resulted in clinical improvement. Histologically re-epithelialization could be demonstrated below the necrotic epidermis. However, on the eighteenth day of skin disease (10 days after discontinuation of phenytoin and 8 days after the start of dexamethasone pulse therapy), a histologically verified rebound-TEN developed with a detachment of 95%. Oxazepam was stopped and a second series of dexamethasone pulse therapy was given. Re-epithelialization began within 24 h of the start of the second series of dexamethasone pulse therapy, and continued to almost complete recovery within 1 week. |
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Authors:
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J B van der Meer; M L Schuttelaar; G G Toth; S H Kardaun; G Beerthuizen; M C de Jong; M F Jonkman; P Nieuwenhuis |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: 26 ISSN: 0307-6938 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-27 Completed Date: 2002-01-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 654-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology (Centre of Blistering Skin Diseases), Faculty of Medical Sciences, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands. secreteriaat@derm.azg.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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therapeutic use Brain Neoplasms / drug therapy, secondary Dexamethasone / administration & dosage* Drug Therapy, Combination Epidermal Necrolysis, Toxic / drug therapy*, etiology*, pathology Epidermis / drug effects, pathology Female Glucocorticoids / administration & dosage* Humans Hypnotics and Sedatives / adverse effects* Lung Neoplasms / drug therapy Middle Aged Oxazepam / adverse effects* Phenytoin / therapeutic use Pulse Therapy, Drug |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Glucocorticoids; 0/Hypnotics and Sedatives; 50-02-2/Dexamethasone; 57-41-0/Phenytoin; 604-75-1/Oxazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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