| Successful desensitization to immunoglobulin A in a case of transfusion-related anaphylaxis. | |
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MedLine Citation:
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PMID: 20456696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A history of anaphylaxis after transfusion of immunoglobulin A (IgA)-containing blood products in selective IgA-deficient (sIgAD) patients can be a major problem, particularly in emergencies, when large quantities of blood products are required. CASE REPORT: A 19-year-old woman with end-stage Type 2 autoimmune hepatitis required liver transplantation as her only remaining treatment option. However, she also had sIgAD, anti-IgA antibodies, and episodes of anaphylaxis after receiving IgA-containing blood products. Liver transplantation would have been extremely challenging due to the difficulty of obtaining sufficient blood products from suitable IgA-deficient donors. Hence, it became imperative to devise a protocol to desensitize her to IgA-containing blood products. RESULTS: Using a continuous infusion of an IgA-enriched (6 mg/mL IgA) immunoglobulin preparation with gradual increases in concentration, she was successfully desensitized to IgA. Consequently, she was able to receive standard platelets, fresh-frozen plasma, and red blood cells with no complications. CONCLUSION: This approach could prove very useful in similar cases that may require administration of large quantities of blood products particularly in emergency lifesaving circumstances. |
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Authors:
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Sorena Kiani-Alikhan; Patrick F K Yong; Dorothea Grosse-Kreul; Susan E Height; Aleksandar Mijovic; Abid R Suddle; Mohammad A A Ibrahim |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Transfusion Volume: 50 ISSN: 1537-2995 ISO Abbreviation: Transfusion Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-11-05 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: United States |
Other Details:
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Languages: eng Pagination: 1897-901 Citation Subset: IM |
Copyright Information:
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© 2010 American Association of Blood Banks. |
Affiliation:
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Department of Clinical Immunology and Allergy, Institute of Liver Studies, King's College Hospital, London, UK. skiani@nhs.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anaphylaxis / etiology*, immunology, prevention & control* Blood Transfusion / adverse effects* Female Humans Immunoglobulin A / immunology*, therapeutic use* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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