Document Detail

Successful conservative treatment of endometrial carcinoma permitting subsequent pregnancy: report of two cases.
MedLine Citation:
PMID:  10843466     Owner:  NLM     Status:  MEDLINE    
Two women with endometrial carcinoma who wished to preserve their childbearing ability received conservative treatment by medroxyprogesterone acetate (MPA, 600 mg/day for 22 weeks and 29 weeks, respectively). Following regression of endometrial lesions, their infertility was treated by inducing ovulation. Intact pregnancy was diagnosed 13 months and 11 months after completion of the MPA treatment, respectively. One patient had a twin pregnancy and delivered two infants at 35 weeks of gestational age. The other patient delivered a full-term baby. They had no evidence of recurrence 60 months and 31 months after the conservative treatment, respectively. We believe this conservative treatment with progestin may be safely performed for young patients with endometrial cancer who wish to preserve their fertility.
T Jobo; M Imai; M Kawaguchi; M Kenmochi; H Kuramoto
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of gynaecological oncology     Volume:  21     ISSN:  0392-2936     ISO Abbreviation:  Eur. J. Gynaecol. Oncol.     Publication Date:  2000  
Date Detail:
Created Date:  2000-09-26     Completed Date:  2000-09-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8100357     Medline TA:  Eur J Gynaecol Oncol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Department of Obstetrics and Gynecology, School of Medicine, Kitasato University, Kanagawa, Japan.
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MeSH Terms
Adenocarcinoma / diagnosis,  drug therapy*,  pathology*
Drug Administration Schedule
Endometrial Neoplasms / diagnosis,  drug therapy*,  pathology*
Follow-Up Studies
Medroxyprogesterone / administration & dosage*
Progesterone Congeners / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Progesterone Congeners; 520-85-4/Medroxyprogesterone

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