Document Detail

Successful closure of the patent ductus arteriosus by indomethacin in an extremely low birth weight infant of very advanced postnatal age.
MedLine Citation:
PMID:  9568226     Owner:  NLM     Status:  MEDLINE    
Many studies demonstrate the efficacy of closure of a patent ductus arteriosus with indomethacin, but also show that success diminishes markedly with increasing postnatal age. For this reason surgical ligation is usually preferred after the first month of life. We describe the case of a male premature infant (25 weeks gestation, birth weight 680 g), in whom a PDA was successfully closed with indomethacin (0.1 mg/kg once daily intravenously for 6 days) at the age of 11 weeks. Thus it may be concluded that closure by drug may be attempted before surgical ligation even in cases of advanced postnatal age.
W Sterniste; C Gabriel; M Sacher
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric cardiology     Volume:  19     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-05-21     Completed Date:  1998-05-21     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  256-8     Citation Subset:  IM    
Pediatric Department, Danube Hospital, Vienna, Austria.
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MeSH Terms
Cyclooxygenase Inhibitors / therapeutic use*
Ductus Arteriosus, Patent / drug therapy*
Indomethacin / therapeutic use*
Infant, Very Low Birth Weight*
Injections, Intravenous
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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