| Successful clearance of catheter-related bloodstream infection by antibiotic lock therapy using ampicillin. | |
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MedLine Citation:
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PMID: 16449537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case in which ampicillin was used successfully as lock therapy for a central venous intravascular catheter and to discuss the implications of ampicillin used in this modality. CASE SUMMARY: A 14-month-old girl with a long-term central venous catheter acquired a polymicrobial (Escherichia coli and Enterococcus durans) bloodstream infection. The central venous catheter was suspected as the source for the bacteremia based on the timing and number of positive blood cultures in relation to therapy with antibiotics. Antibiotic sensitivity testing revealed ampicillin monotherapy to be an ideal choice to treat both organisms. A combination of systemic therapy via a temporary catheter and antibiotic lock therapy of the central venous catheter was then instituted using ampicillin without anticoagulants. The patient tolerated this therapy without complications, and follow-up cultures demonstrated effective clearance of the bacteria. DISCUSSION: Antibiotic lock therapy has been shown to be useful in the treatment of catheter-related bloodstream infections. However, many antibiotics have yet to be tested with this modality. Ampicillin, which is frequently used in the treatment of Enterococcus and E. coli infections, has not previously been reported as a single agent for lock therapy. CONCLUSIONS: Ampicillin may be a useful agent with the relatively new modality of lock therapy for central venous catheters. Further studies are needed to demonstrate possible compatibility of this agent with anticoagulants, such as heparin, as well as its efficacy in treating catheter-related bloodstream infections. |
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Authors:
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Robert L Elwood; Steven E Spencer |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-01-31 |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 40 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-07 Completed Date: 2006-03-31 Revised Date: 2006-10-13 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 347-50 Citation Subset: IM |
Affiliation:
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Department of Pediatric Infectious Disease, Walter Reed Army Hospital Center, Washington, DC 20307-5001, USA. Robert.Elwood@NA.AMEDD.ARMY.MIL |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ampicillin
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administration & dosage,
therapeutic use* Anti-Bacterial Agents / administration & dosage, therapeutic use* Bacteremia / drug therapy*, etiology, microbiology Catheterization, Central Venous / adverse effects* Escherichia coli Infections / drug therapy*, etiology, microbiology Female Gram-Positive Bacterial Infections / drug therapy*, etiology, microbiology Humans Infant Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 69-53-4/Ampicillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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