| Successful chemotherapeutic treatment of diencephalic syndrome with continued tumor presence. | |
| | |
MedLine Citation:
|
PMID: 10897816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A 7-month-old infant with typical features of diencephalic syndrome (DES) associated with a hypothalamic mass, most probably a glioma, was treated with chemotherapy. The tumor showed clear shrinkage, but after more than 2 years regrowth was noted. During the treatment period the child regained normal growth and became free of symptoms. As radiation therapy, especially at a young age, has significant adverse effects and a neurosurgical approach to the diencephalic region also has the potential to cause significant sequelae, a chemotherapeutic option, when it exists, is preferred. Thus, in an infant in whom a glioma is suspected to be the cause of the DES, based on the clinical picture and the neuroimaging appearance, chemotherapy should be considered the primary therapeutic modality. Even if its effect is temporary, its use is well justified. The most appropriate treatment protocol still needs to be determined. |
| | |
Authors:
|
A Shuper; I Bloch; L Kornreich; G Horev; S Michowitz; R Zaizov; I Cohen |
Related Documents
:
|
9180056 - Ethical decision-making in newborn infants. 17448746 - Three recurrent episodes of malrotation in an infant. 7850446 - The use of long-acting oxytetracycline for the treatment of ovine footrot. 6658456 - Memory retrieval: a time-locked process in infancy. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Pediatric hematology and oncology Volume: 13 ISSN: 0888-0018 ISO Abbreviation: Pediatr Hematol Oncol Publication Date: 1996 Sep-Oct |
Date Detail:
|
Created Date: 2000-08-25 Completed Date: 2000-08-25 Revised Date: 2006-04-24 |
Medline Journal Info:
|
Nlm Unique ID: 8700164 Medline TA: Pediatr Hematol Oncol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 443-9 Citation Subset: IM |
Affiliation:
|
National Center for Pediatric Hematology/Oncology, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abducens Nerve Diseases
/
etiology Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Brain Neoplasms / complications*, drug therapy Carboplatin / administration & dosage Dactinomycin / administration & dosage Diencephalon / pathology* Failure to Thrive / etiology* Glioma / complications*, drug therapy Growth Disorders / etiology* Humans Hyperkinesis / etiology* Infant Magnetic Resonance Imaging Male Neoplasm Recurrence, Local Nerve Compression Syndromes / etiology Nystagmus, Pathologic / etiology* Remission Induction Strabismus / etiology Vincristine / administration & dosage Weight Gain |
| Chemical | |
Reg. No./Substance:
|
41575-94-4/Carboplatin; 50-76-0/Dactinomycin; 57-22-7/Vincristine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myelotoxicity, pharmacokinetics, and relapse rate with methotrexate/6-mercaptopurine maintenance the...
Next Document: Human herpesvirus-6 (HHV-6)-associated hemophagocytic syndrome.