| Successful challenge with clozapine in a history of eosinophilia. | |
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MedLine Citation:
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PMID: 9988365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eosinophilia has been encountered from 0.2 to 61.7% in clozapine-treated patients, mostly with a transient course and spontaneous remission. There have been few reports, however, which have investigated a challenge with clozapine in patients previously showing eosinophilia. Two case reports are presented: the first with clozapine challenge after eosinophilia, the second under clozapine treatment and no previous haematological side effects. The challenge case showed eosinophilia with 1.2 10(9)/l (z = 1.79, p = 0.04) being followed by normalization despite clozapine continuation, whereas the maximum value reached 2.1 10(9)/l in the single episode case, with consecutive normalization and uninterrupted treatment. Eosinophilia caused by clozapine was observed in challenge, preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01). A challenge with clozapine was feasible and showed no clinical symptoms of eosinophilia. |
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Authors:
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D Schuepbach; M C Merlo; L Kaeser; H D Brenner |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: International clinical psychopharmacology Volume: 13 ISSN: 0268-1315 ISO Abbreviation: Int Clin Psychopharmacol Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1999-04-02 Completed Date: 1999-04-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8609061 Medline TA: Int Clin Psychopharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 33-7 Citation Subset: IM |
Affiliation:
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Psychiatric Services of the University of Berne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antipsychotic Agents / administration & dosage, adverse effects* Clozapine / administration & dosage, adverse effects* Depressive Disorder / drug therapy Eosinophilia / chemically induced* Humans Male Schizophrenia / drug therapy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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