Document Detail

Successful challenge with clozapine in a history of eosinophilia.
MedLine Citation:
PMID:  9988365     Owner:  NLM     Status:  MEDLINE    
Eosinophilia has been encountered from 0.2 to 61.7% in clozapine-treated patients, mostly with a transient course and spontaneous remission. There have been few reports, however, which have investigated a challenge with clozapine in patients previously showing eosinophilia. Two case reports are presented: the first with clozapine challenge after eosinophilia, the second under clozapine treatment and no previous haematological side effects. The challenge case showed eosinophilia with 1.2 10(9)/l (z = 1.79, p = 0.04) being followed by normalization despite clozapine continuation, whereas the maximum value reached 2.1 10(9)/l in the single episode case, with consecutive normalization and uninterrupted treatment. Eosinophilia caused by clozapine was observed in challenge, preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01). A challenge with clozapine was feasible and showed no clinical symptoms of eosinophilia.
D Schuepbach; M C Merlo; L Kaeser; H D Brenner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International clinical psychopharmacology     Volume:  13     ISSN:  0268-1315     ISO Abbreviation:  Int Clin Psychopharmacol     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1999-04-02     Completed Date:  1999-04-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8609061     Medline TA:  Int Clin Psychopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
Psychiatric Services of the University of Berne, Switzerland.
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MeSH Terms
Antipsychotic Agents / administration & dosage,  adverse effects*
Clozapine / administration & dosage,  adverse effects*
Depressive Disorder / drug therapy
Eosinophilia / chemically induced*
Schizophrenia / drug therapy
Treatment Outcome
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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