Document Detail

Successful blood pressure control with additive administration of eplerenone, an aldosterone receptor blocker, in a patient with bilateral renovascular hypertension treated with angioplasty.
MedLine Citation:
PMID:  21088349     Owner:  NLM     Status:  MEDLINE    
A 29-year-old woman with refractory hypertension who previously suffered from subarchnoid hemorrhage visited our facility. The diagnosis of renovascular hypertension due to fibromuscular dysplasia was made based on a high level of plasma renin activity (PRA) and aldosterone concentration (AC), and computed tomographic image of bilateral renal artery stenosis/obstruction. Angioplasty, which could be performed only to the left renal artery, failed to regain sufficient BP control. The addition of eplerenone, an aldosterone receptor blocker, to the conventional antihypertensive drugs successfully and safely lowered BP and preserved the renal function despite the persistence of high PRA and AC values.
Chikao Ibuki; Hiroshi Kawamata; Yoshihiko Seino; Kyoichi Mizuno
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-11-15
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  49     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-22     Completed Date:  2011-03-23     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2455-9     Citation Subset:  IM    
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MeSH Terms
Hypertension, Renovascular / drug therapy*
Mineralocorticoid Receptor Antagonists / therapeutic use*
Remission Induction
Spironolactone / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Mineralocorticoid Receptor Antagonists; 27O7W4T232/Spironolactone; 6995V82D0B/eplerenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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