Document Detail

Successful birth following transfer of frozen-thawed embryos produced from in-vitro matured oocytes.
MedLine Citation:
PMID:  20541467     Owner:  NLM     Status:  MEDLINE    
It is well established that ovarian hyperstimulation syndrome (OHSS) is more frequent in patients with polycystic ovarian syndrome. In-vitro maturation (IVM) of immature oocytes presents a potential alternative for the fertility treatment and prevention of OHSS for these patients. This report describes the case of a 26-year old woman with a successful pregnancy and delivery following the transfer of frozen-thawed embryos derived from in-vitro matured oocytes. She had three failed cycles of ovarian stimulation (using low-dose step-up gonadotrophin protocol) with or without intrauterine insemination cycles, an ovulation-induction cycle with luteal long protocol, two fresh IVM cycle and one frozen-thawed IVM cycle. During the IVF cycle, she developed moderate OHSS and required hospitalization for 3 weeks. Following four unsuccessful IVF or IVM cycles, 15 months after the last cryopreservation, six fertilized oocytes were thawed for a scheduled embryo transfer. Following thawing, four fertilized oocytes survived and cleaved. Four frozen-thawed embryos were transferred. Six weeks after embryo transfer an ongoing intrauterine single pregnancy with fetal heartbeat was confirmed by transvaginal ultrasound. An uneventful pregnancy and delivery via Caesarean section at 39 weeks resulted in the birth of a normal healthy infant.
Aygul Demirol; Suleyman Guven; Moncef Benkhalifa; Tamer Sari; Timur Gurgan
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-04-24
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  21     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  215-8     Citation Subset:  IM    
Copyright Information:
2010. Published by Elsevier Ltd.
Gurgan Clinic Women Health, Infertility and IVF Center, Cankaya Caddesi, No. 20/3, Ankara, Turkey.
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MeSH Terms
Embryo Transfer*
Ovarian Hyperstimulation Syndrome / physiopathology
Ovulation Induction
Pregnancy Outcome*

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