Document Detail

Successful application of pentoxifylline in the treatment of HTLV-I associated myelopathy.
MedLine Citation:
PMID:  9335018     Owner:  NLM     Status:  MEDLINE    
Fifteen patients with human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy (HAM) were treated in an uncontrolled preliminary trial by oral administration of pentoxifylline (PTX). Motor function, neurological evaluation, immunological markers and parameters were evaluated after four weeks. In 13 of the 15 patients, motor disability, especially spasticity, improved substantially. PTX suppressed spontaneous proliferation of peripheral blood mononuclear cells in 14 of the 15 patients at four weeks. No adverse effect was observed. We concluded that PTX may be a safe and beneficial agent for the treatment of HAM.
S Shirabe; T Nakamura; A Tsujino; Y Nishiura; T Furuya; H Goto; A Suenaga; S Nakane; T Yoshimura; S Nagataki
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  151     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-20     Completed Date:  1997-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  97-101     Citation Subset:  IM; X    
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
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MeSH Terms
Middle Aged
Paraparesis, Tropical Spastic / drug therapy*
Pentoxifylline / adverse effects,  therapeutic use*
Prospective Studies
Treatment Outcome
Vasodilator Agents / adverse effects,  therapeutic use*
Viral Load
Reg. No./Substance:
0/Vasodilator Agents; 6493-05-6/Pentoxifylline

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