| Successful aortic valve replacement for Heyde syndrome with confirmed hematologic recovery. | |
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MedLine Citation:
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PMID: 17184682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aortic valve stenosis can be complicated by recurrent gastrointestinal bleeding, particularly that due to angiodysplasia, also called Heyde syndrome. Recently, acquired type 2A von Willebrand disease, which is characterized by the loss of the large multimer of von Willebrand factor by the shear stress of aortic valve stenosis, was reported to be associated with this hemorrhagic syndrome. A 78-year-old woman, with severe aortic stenosis, presented with advanced anemia due to recurrent gastrointestinal bleeding and was diagnosed Heyde syndrome. By perioperative supplementation of von Willebrand factor and factor VIII, aortic valve replacement was safely performed without gastrointestinal bleeding. After the operation, the multimer of von Willebrand factor was normalized and thereafter no gastrointestinal bleeding occurred. This case reports the successful aortic valve replacement for Heyde syndrome, with confirmed hematologic recovery. |
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Authors:
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Atsutomo Morishima; Akira Marui; Takeshi Shimamoto; Yoshiaki Saji; Keiichi Tambara; Takeshi Nishina; Masashi Komeda |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 83 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-22 Completed Date: 2007-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 287-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiodysplasia / complications* Aortic Valve / surgery* Aortic Valve Stenosis / surgery* Cardiopulmonary Bypass Female Gastrointestinal Hemorrhage / etiology* Humans Syndrome von Willebrand Factor / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/von Willebrand Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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