Document Detail

Successful administration of alteplase in a venous thromboembolism crossing through a patent foramen ovale.
MedLine Citation:
PMID:  19592415     Owner:  NLM     Status:  MEDLINE    
We describe a case report observed via an echocardiography of a venous thromboembolism (VTE) that crosses through the patent foramen ovale to the left atrium and is successfully treated with alteplase. This is a case report of a tertiary care hospital without cardiac surgery facilities. An 81-year-old female seeking medical attention for dyspnoea, arriving at hospital with hypoxaemia, hypotension and prerenal failure. A computed tomographic (CT) pulmonary angiography was carried out, revealing a VTE. A transesophageal echocardiography (TEE) was carried out, exposing emboli in the right cavities, said thrombus crossing through the patent foramen ovale to the left atrium. A systemic thrombolysis is carried out using alteplase which improves the patient's condition and results in the disappearance of thrombotic images in the various cardiac cavities. The evolution is positive and there is no evidence of embolic or haemorrhagic complications. When a paradoxical embolism is present, in the context of a serious VTE, carrying out thrombolysis could be a therapeutic option.
Manuel Ruiz-Bailén; Jose Angel Ramos-Cuadra; Juan Machado-Casas; Luis Rucabado-Aguilar
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-07-10
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  9     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-23     Completed Date:  2009-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  712-3     Citation Subset:  IM    
Department of Critical Care and Emergency, Intensive Care Unit, Hospital Universitario Médico-Quirúrgico del Complejo Hospitalario de Jaén, University of Jaén, Spain.
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MeSH Terms
Aged, 80 and over
Echocardiography, Transesophageal
Embolism, Paradoxical / diagnosis,  drug therapy*,  etiology
Fibrinolytic Agents / administration & dosage*
Foramen Ovale, Patent / complications*,  diagnosis
Health Services Accessibility
Thrombolytic Therapy*
Tissue Plasminogen Activator / administration & dosage*
Tomography, X-Ray Computed
Treatment Outcome
Venous Thromboembolism / complications,  diagnosis,  drug therapy*
Reg. No./Substance:
0/Fibrinolytic Agents; EC Plasminogen Activator
Comment In:
Interact Cardiovasc Thorac Surg. 2009 Oct;9(4):714   [PMID:  19773241 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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