| Successful treatment of thyroid storm with plasmapheresis in a patient with methimazole-induced agranulocytosis. | |
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MedLine Citation:
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PMID: 20439250 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case of a patient with Graves disease presenting with agranulocytosis induced by methimazole, with subsequent thyroid storm and successful therapeutic use of plasmapheresis. METHODS: The clinical features and laboratory findings in a patient with agranulocytosis and thyroid storm are presented, and the available literature on utilization of plasmapheresis in the setting of thyrotoxicosis is reviewed. RESULTS: A 40-year-old Vietnamese woman with Graves disease was admitted with methimazole-induced agranulocytosis. Treatment with methimazole was discontinued, and therapy with antibiotics, granulocyte colony-stimulating factor, and ibuprofen was initiated. During hospitalization of the patient, her clinical status deteriorated, with development of pericarditis, thrombocytopenia, and thyroid storm. Treatment with plasmapheresis yielded near-euthyroidism in 3 days. Subsequently, she underwent successful total thyroidectomy. CONCLUSION: Our case highlights the effectiveness of plasmapheresis when clinical situations prohibit the use of traditional treatment methods for thyrotoxicosis or thyroid storm (or both). |
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Authors:
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Ashish A Vyas; Priyanka Vyas; Nicole Lynn Fillipon; Rajakrishnan Vijayakrishnan; Nitin Trivedi |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 16 ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-08-13 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
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Languages: eng Pagination: 673-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Agranulocytosis / chemically induced, complications*, immunology Antithyroid Agents / adverse effects* Female Graves Disease / complications, drug therapy, immunology Humans Methimazole / adverse effects* Plasmapheresis* Thyroid Crisis / complications*, immunology, surgery, therapy* Thyroidectomy Thyrotoxicosis / immunology, therapy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antithyroid Agents; 60-56-0/Methimazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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