| Successful treatment of POEMS syndrome complicated by severe congestive heart failure with thalidomide. | |
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MedLine Citation:
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PMID: 20190484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 55-year-old woman was diagnosed with POEMS syndrome; however, we could not perform high-dose chemotherapy with autologous peripheral blood stem cell transplantation (auto-PBSCT) because of rapidly progressive congestive heart failure. Thus, we treated the patient with thalidomide plus dexamethasone, which brought about a marked improvement of systolic dysfunction, POEMS syndrome-related symptoms and the serum concentrations of vascular endothelial growth factor. Subsequently, we safely performed high-dose chemotherapy with auto-PBCST. This report strongly suggests that thalidomide is effective for POEMS syndrome, even if complicated by congestive heart failure which is considered to be related to POEMS syndrome. |
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Authors:
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Daichi Inoue; Aiko Kato; Sumie Tabata; Takeshi Kitai; Yoko Takiuchi; Takaharu Kimura; Sonoko Shimoji; Minako Mori; Yuya Nagai; Katsuhiro Togami; Akiko Matsushita; Kenichi Nagai; Hayato Maruoka; Yukihiro Imai; Minako Beppu; Michi Kawamoto; Takayuki Takahashi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-03-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-05-13 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 461-6 Citation Subset: IM |
Affiliation:
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Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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therapeutic use* Dexamethasone / therapeutic use* Drug Therapy Drug Therapy, Combination Female Heart Failure / drug therapy*, etiology* Humans Middle Aged POEMS Syndrome / complications*, drug therapy* Peripheral Blood Stem Cell Transplantation Thalidomide / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 50-02-2/Dexamethasone; 50-35-1/Thalidomide |
| Comments/Corrections | |
Comment In:
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Intern Med. 2010;49(17):1919; author reply 1921
[PMID:
20823658
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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