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Successful Pregnancy and Delivery in a Patient with Chronic Myeloid Leukemia while on Dasatinib Therapy.
MedLine Citation:
PMID:  20224653     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Here we report the case of an 18-year-old woman with chronic myeloid leukemia (CML) who became pregnant while undergoing treatment with dasatinib. Before pregnancy, she received imatinib mesylate therapy but could not tolerate the treatment. The regimen was then changed to dasatinib at a dose of 70 mg b.i.d. While she was in hematological remission and on dasatinib therapy, she became pregnant. The unplanned pregnancy was identified after the patient had experienced four weeks of amenorrhea. Because the patient elected to continue the pregnancy to term, dasatinib was stopped immediately. Meanwhile, CML hematological relapse occurred and then she was treated with interferon-alpha (IFN-alpha) (9 million IU/day) throughout the pregnancy without a complete hematological response. She successfully gave birth to a male baby at 33 weeks by cesarean section delivery with no sequelae or malformations. Although this experience is limited to a single patient, it provides a useful contribution for counselling patients inadvertently exposed to dasatinib during pregnancy.
Authors:
Monika Conchon; Sabri S Sanabani; Mariana Serpa; Mafalda M Y Novaes; Luciana Nardinelli; Patrícia B Ferreira; Pedro Enrique Dorliac-Llacer; Israel Bendit
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Publication Detail:
Type:  Journal Article     Date:  2010-03-07
Journal Detail:
Title:  Advances in hematology     Volume:  2010     ISSN:  1687-9112     ISO Abbreviation:  Adv Hematol     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504271     Medline TA:  Adv Hematol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  136252     Citation Subset:  -    
Affiliation:
Department of Hematology, Faculty of Medicine, University of São Paulo, SP 05403-000, Brazil.
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