Document Detail

Successful peritoneal dialysis in a hemophilia A patient with factor VIII inhibitor.
MedLine Citation:
PMID:  20056993     Owner:  NLM     Status:  MEDLINE    
Chronic kidney disease and need for renal replacement therapy in hemophiliacs are relatively rare occurrences. Successful hemodialysis and peritoneal dialysis applications have been reported in the literature. We report a difficult-to-manage patient with hemophilia A plus factor VIII inhibitor who presented with gastrointestinal bleeding complicated by uremia. We admitted this hemophilia A patient with gastrointestinal bleeding who did not take regular factor infusions. He also had chronic kidney disease due to urinary stone disease. Since uremia might have contributed to bleeding, we chose hemodialysis along with factor VIII supplementation. His factor VIII and factor VIII inhibitor levels were 4% and 5 Bethesda units respectively. In order to bypass the inhibitor, we applied factor VIIA and prothrombin complex concentrate. After cessation of the hemorrhage, we placed a Tenckhoff catheter under prothrombin complex concentrate infusion. We did not observe any perioperative complication. To our knowledge, this is the first report of successful peritoneal dialysis in a hemophilia A patient who had factor VIII inhibitors.
Y Solak; K Turkmen; H Atalay; S Turk
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Publication Detail:
Type:  Case Reports; Letter    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  30     ISSN:  1718-4304     ISO Abbreviation:  Perit Dial Int     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-01-08     Completed Date:  2011-02-01     Revised Date:  2012-08-08    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  114-6     Citation Subset:  IM    
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MeSH Terms
Factor VIII / immunology*
Hemophilia A / complications*,  immunology
Kidney Failure, Chronic / complications*,  immunology,  therapy*
Middle Aged
Peritoneal Dialysis*
Reg. No./Substance:
9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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