Document Detail

Successful Management of a Possible Antibiotic-Related Acquired Factor V Inhibitor: A Case Report and Review of the Literature.
MedLine Citation:
PMID:  23257771     Owner:  NLM     Status:  Publisher    
Acquired factor inhibitors are rare. We report a case of an elderly male who presented with a bleeding diathesis associated with an elevated prothrombin time and an activated partial thromboplastin time. Work-up revealed undetectable factor V activity and a factor V inhibitor level of >50 Bethesda units. The inhibitor may have been triggered by antibiotics. With a multimodality approach using steroids, platelet transfusions, intravenous immunoglobulin, factor VIII inhibitor bypass activity agent and cyclophosphamide, we successfully eliminated the inhibitor and controlled the bleeding.
Pooja Motwani; Leslie Howard; Syed S Ali
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-19
Journal Detail:
Title:  Acta haematologica     Volume:  129     ISSN:  1421-9662     ISO Abbreviation:  Acta Haematol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  182-184     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Baystate Medical Center, Springfield, Mass., USA.
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