| Successful management of anti-Jra alloimmunization in pregnancy: a case report. | |
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MedLine Citation:
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PMID: 19923849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hemolytic disease of the fetus/newborn due to Jr(a) immunization is very rare and considered to be mild, and only routine obstetrical care is recommended for pregnant women sensitized to the Jr(a) antigen. CASE REPORT: A 20-year-old nulliparous woman was referred to our hospital for perinatal management. Her indirect Coombs test was positive for anti-Jr(a) antibody (1:64). At 33 weeks' gestational age, we observed that fetal growth was mildly restricted and the peak systolic velocity of the fetal middle cerebral artery (PSV-MCA) was above the upper limit of the reference range (1.55 multiples of the median). Amniocentesis was also carried out and the DeltaOD450 value was in the lower mid-zone of the Liley curve. We continued to carefully observe the patient because we observed PSV-MCA values within 1.50-1.60 multiples of the median and no other findings of fetal anemia. She vaginally delivered a female infant weighing 2,136 g at 37 weeks' gestational age. The infant received treatment with both iron and recombinant erythropoietin without developing hyperbilirubinemia and blood transfusion. CONCLUSION: PSV-MCA should be monitored for the detection of fetal anemia, even in pregnant women sensitized to some antigens for which only routine obstetrical care is recommended. |
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Authors:
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Akio Masumoto; Hisashi Masuyama; Yumi Sumida; Tomonori Segawa; Yuji Hiramatsu |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-11-19 |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 69 ISSN: 1423-002X ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: Switzerland |
Other Details:
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Languages: eng Pagination: 81-3 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Group Incompatibility
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drug therapy,
pathology*,
ultrasonography Erythroblastosis, Fetal / drug therapy, pathology*, ultrasonography Erythropoietin / therapeutic use Female Humans Infant, Newborn Iron / therapeutic use Pregnancy Pregnancy Complications, Hematologic / pathology*, ultrasonography Rh Isoimmunization / drug therapy, pathology*, ultrasonography Young Adult |
| Chemical | |
Reg. No./Substance:
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11096-26-7/Erythropoietin; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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