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Successful catheter ablation of persistent electrical storm late post myocardial infarction by targeting purkinje arborization triggers.
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PMID:  18982139     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Drug refractory ventricular tachycardia (VT) occurring as a storm after acute myocardial infarction has grave prognosis. We report a case of a middle-aged lady who presented with drug refractory VT that lead to persistent electrical storm two weeks after an anterior wall myocardial infarction. She underwent a successful catheter ablation of VT followed a few days later by implantation of an AICD. Catheter ablation of the VT could control the persistent electrical storm and the patient was free from a recurrence of VT at three month follow up.
Authors:
Paul S Thoppil; B Hygriv Rao; S Jaishankar; Calambur Narasimhan
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Publication Detail:
Type:  Journal Article     Date:  2008-11-01
Journal Detail:
Title:  Indian pacing and electrophysiology journal     Volume:  8     ISSN:  0972-6292     ISO Abbreviation:  Indian Pacing Electrophysiol J     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-04     Completed Date:  2010-05-20     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  101157207     Medline TA:  Indian Pacing Electrophysiol J     Country:  India    
Other Details:
Languages:  eng     Pagination:  298-303     Citation Subset:  -    
Affiliation:
Division of Electrophysiology, Department of Cardiology, CARE Hospitals and CARE Foundation, Hyderabad, India.
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Journal Information
Journal ID (nlm-ta): Indian Pacing Electrophysiol J
Journal ID (publisher-id): Indian Pacing Electrophysiol J
ISSN: 0972-6292
Publisher: Indian Heart Rhythm Society
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Copyright: ? 2008 Thoppil et al.
open-access: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
collection publication date: Season: Oct?Dec Year: 2008
Electronic publication date: Day: 01 Month: 11 Year: 2008
Volume: 8 Issue: 4
First Page: 298 Last Page: 303
ID: 2572020
PubMed Id: 18982139
Publisher Id: ipej080298-00

Successful Catheter Ablation of Persistent Electrical Storm late Post Myocardial Infarction by Targeting Purkinje Arborization Triggers
Paul S Thoppil, MD, DM
B Hygriv Rao, MD, DM
S Jaishankar, MD, DM
Calambur Narasimhan, MD,DM,AB
Division of Electrophysiology, Department of Cardiology, CARE Hospitals and CARE Foundation, Hyderabad, India
Correspondence: Address for correspondence: Dr C Narasimhan, CARE hospitals and CARE foundation, Exhibition Road, Nampally Hyderabad-500001, India. E-mail: calambur@hotmail.com

Introduction

The incidence of incessant drug refractory ventricular tachycardia (VT) after a remote myocardial infarction (MI) is quoted to be 10% [1]. Presentation as an electrical storm occurs in 1%, and is associated with 50% mortality if it manifests within a week after an acute MI [2]. The success rate of catheter ablation of post myocardial infarction VT has steadily increased in recent years on account of improved understanding of the underlying mechanisms that cause ischemic VT. We report a patient who presented in persistent electrical storm two weeks after acute MI and successfully underwent successful catheter ablation of arborizing purkinje triggers near the border-zone of MI where the VT was being initiated.


Case Report

A 62 years old lady was admitted to an outside facility with evolved anterior wall myocardial infarction and had undergone rescue angioplasty and stenting of single vessel disease in left anterior descending coronary artery (LAD) under cover of Eptifibatide. Ten days after the stenting she developed recurrent episodes of monomorphic VT (at 180/mt, RBBB morphology, North West axis, Figure 1) and presented in an electrical storm unresponsive to multiple antiarrhythmic drugs (IV beta blockers, amiodarone, lidocaine and magnesium), DC shocks, and intraaortic balloon counterpulsation. Overdrive ventricular pacing was performed which was able to restrict VT to around 20 episodes over the previous 24 hr period. The episodes of ventricular tachyarrhythmia were poorly tolerated haemodynamically. An echocardiogram during sinus rhythm had revealed regional wall motion abnormalities in LAD territory and severe LV Dysfunction (LVEF 30%). A check angiogram disclosed a patent stent; there was no thrombus or new lesions. Serum biochemistry, arterial blood gas parameters and thyroid profile were normal. She was referred to our center for feasibility of catheter ablation of VT.

She underwent an emergency electrophysiology study during which many attempts at cardioversion and overdrive pacing failed to control the storm. Access to the left ventricle was achieved retrogradely across the aortic valve. LV mapping was performed using a non-fluoroscopic electroanatomic system (CARTO, Biosense Webster Inc, USA) and 7.5F Navistar F curve irrigated tip catheter. A bipolar LV voltage map was created to define the scar and border zone of MI. The infarct area was defined during sinus rhythm by electrograms with an amplitude ? 1.5 mV; dense scars were defined by electrograms with an amplitude ? 0.5 mV. Once the map was completed, amplitude scale was adjusted (0.2 to 0.5 mV), setting the value for scar at ? 0.2 mV to identify conducting channels within the scar area. They were marked out as corridors of continuous electrograms differentiated from the surrounding scar tissue by a higher amplitude, bounded by two scar areas, or by one scar area and the mitral annulus, and connected to normal myocardium by at least two sites [3]. A large scar at anterolateral wall and apex of LV was mapped and the infarct area was completely encircled. RF lesions were delivered using an irrigated tip catheter at 30 W power, 43?C temperature with an irrigation rate of 20 to 30 mL/min. Whenever a conducting channel was identified along the border zone of scar, a RF lesion was immediately applied to transect the conducting channel. Following the initial ablation of conducting channels and of sites of LV tagged by late diastolic potentials (Figure 2), the VT storm terminated temporarily but the monomorphic VT could still be reinduced on programmed ventricular stimulation during isoprenaline infusion. Pace mapping at various endocardial LV sites did not produce an ideal match of clinical VT and hence that course was not pursued further. A further substrate mapping of LV revealed a discrete Purkinje potential preceding spontaneous ventricular ectopic beat (which was not evident in sinus beats ), suggesting a driver role in the sustenance of the tachycardia (Figure 3). RF lesions were delivered at the LV sites where Purkinje potential preceded the ventricular activation by ? 30 ms during ventricular ectopic beats and during tachycardia (Figure 4). After this targeted ablation of Purkinje potential triggers, VT became noninducible with aggressive programmed ventricular stimulation during isoprenaline infusion. A single chamber ICD was implanted a week later and she was discharged in a stable condition. No recurrence of VT or ICD shocks occurred in the two month follow-up.


Discussion

Electrical storm, defined originally as = 3 distinct episodes of VT/VF within 24-hour period that occurs in ICD recipients, can rarely occur in the few weeks following AMI [4] and when becomes persistent, is very difficult to treat. Nademanee et al [2] have pointed out the superiority of sympathetic blockade (left stellate ganglionic blockade and ?-blockade) over antiarrhythmic drug therapy (Lidocaine, Procainamide, Bretylium). The 1 week mortality rate with antiarrhythmic drug therapy was significantly higher than with sympathetic blockade (82% Vs 22%) [2]. In the same study the 1 year VF-free survival for sympathetic blockade group was 67% versus 5% for antiarrhythmic drug therapy group but the VT burden during follow up was not clearly stated. The overall morality rate of patients with electrical storm after AMI remains still high even with antiarrhythmic drug therapy and sympathetic blockade. SMASH-VT trial results revealed that after substrate based catheter ablation there was 65% reduction in delivery of therapy for VT in patients with a history of AMI who received ICDs for the secondary prevention of sudden death [5]. The acute success rate of catheter ablation of recurrent VT after myocardial infarct by combined contact and non contact mapping has been reported to range between 67% and 77% [6].

RF ablation of VT soon after myocardial infarction is more difficult and often challenging, but a need for an attempt at ablation always exists since the mortality rate remains high even with combination antiarrhythmic drug therapy and left stellate ganglionic blockade. Both activation mapping and approaches during sinus rhythm have been shown to be effective methods for ablation of VT. Previous studies conducted on arrhythmias soon after experimental acute myocardial infarction have suggested different kinds of mechanisms responsible for its occurrence. They include enhanced automaticity of subendocardial Purkinje fibers that survived myocardial infarction [7], triggered activity arising from delayed afterdepolarizations [8], and reentry [9]. The damaged border zone area of the scar resulting from MI has been demonstrated to play a crucial role in forming the substrate that sustains macro-reentry and monomorphic VT [10,11]. In such a VT, activation and entrainment mapping allows determination of the critical isthmus of slowed conduction that sustains VT and thus facilitates successful ablation of VT. Activation mapping during the arrhythmia was technically challenging in our patient as she became haemodynamically unstable during sustained VT. Mapping could be performed by ventricular pacing at constant cycle length (550 ms) and later by substrate mapping once VT terminated to sinus rhythm. Ablation after prolonged activation mapping and pace-mapping of endocardial LV was not successful in producing sustained sinus rhythm. It was only after application of RF lesions at the LV sites which demonstrated purkinje potentials preceding ventricular activation that a stable sinus rhythm could be achieved and no VT could be reinduced. Interestingly, the Purkinje fibers have been demonstrated as capable of surviving transmural infarction in experimental models, leading to a speculation that their proximity to the endocardium allows imbibition of nutrients from intracavitary blood [7]. The surviving Purkinje fibers that cross the border zone of the MI demonstrate triggered activity, heightened automaticity, and supernormal excitability, which when coupled with prolongation of the action potential duration in this area, may result in the milieu for triggering VT [12,13].

Incessant ventricular tachyarrhythmia soon after MI leading to drug-resistant electrical storm is a rare but technically challenging entity. A search for various triggers that initiate refractory VT should be meticulously made to enhance the success rates of catheter ablation of the VT and to use it as a bailout therapy in these patients.


References
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Nademanee, Koonlawee;Taylor, Richard;Bailey, WE.,et al. Treating Electrical Storm: Sympathetic Blockade versus Advanced Cardiac Life Support-Guided TherapyCirculation 2000;102:742–747. [pmid: 10942741]
Carbucicchio, Corrado;Santamaria, Matteo;Trevisi, Nicola,et al. Catheter Ablation for the Treatment of Electrical Storm in Patients With Implantable Cardioverter-DefibrillatorsCirculation 2008;117:462–469. [pmid: 18172038]
Exner DV,Pinski SL Jr,Wyse George,et al. Electrical Storm Presages Nonsudden Death: The Antiarrhythmics Versus Implantable Defibrillators (AVID) TrialCirculation 2001;103:2066–2071. [pmid: 11319196]
Reddy, Vivek Y.;Ronalds, Mathew R.;Allison, PN.,et al. Prophylactic catheter ablation for prevention of Defibrillator therapyN Engl J Med 2007;357:2657–2665. [pmid: 18160685]
Klemm HU,Ventura Rodolfo,Steven Daniel,et al. Catheter Ablation of Multiple Ventricular Tachycardias After Myocardial Infarction Guided by Combined Contact and Noncontact MappingCirculation 2007;115:2697–2704. [pmid: 17502573]
Friedman PL,Stewart JR,Fenoglio JJ,et al. Purkinje fibers after extensive myocardial infarction in dogs: in vitro and in vivo correlationsCirc Res 1973;33:597–611. [pmid: 4752859]
El-Sherif N,Gough WB,Zeiler RH,et al. Triggered ventricular rhythms in 1-day-old myocardial infarctionCirc Res 1983;52:566. [pmid: 6682722]
El-Sherif N,Mehra R,Gough WB,et al. Ventricular activation patterns of spontaneous and induced ventricular rhythms in canine one-day-old myocardial infarction: Evidence for focal and reentrant mechanismsCirc Res 1982;51:52.
Stevenson WG,Khan H,Sager P,et al. Identification of re-entry circuit sites during catheter mapping and radiofrequency ablation of ventricular tachycardia late after myocardial infarctionCirculation 1993;88:1647–1670. [pmid: 8403311]
Soejima K,Suzuki M,Maisel WH,et al. Catheter ablation in patients with multiple and unstable ventricular tachycardias after myocardial infarction: short ablation lines guided by reentry circuit isthmuses and sinus rhythm mappingCirculation 2001;104:664–669. [pmid: 11489772]
Arnar DO,Bullinga JR,Martins JB. Purkinje system in spontaneous ventricular tachycardia during acute ischemia in a canine modelCirculation 1997;96:2421–2429. [pmid: 9337219]
Kupersmith J,Li ZY,Maidonado C. Marked action potential prolongation as a source of injury current leading to border zone arrhythmogenesisAm Heart J 1994;127:1543–1553. [pmid: 8197981]

Article Categories:
  • Case Report

Keywords: Electrical storm, Catheter ablation, Purkinje arborization triggers.

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